Table 1 Characteristics of brain samples analyzed in this study

From: Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP

Sample group

Neuropathologic diagnosis

Sample size

Brain region

Age (years)a

Female (%)

DV200a

Reference

MAPT p.R406W

FTLD-Tau

2

Insular cortex

69.46 ± 3.88

50%

85.33 ± 11.55

23

Controls

None

2

Insular cortex

71.81 ± 2.14

50%

88.5 ± 2.12

23

Sporadic FTLD

FTLD-TDP

11

Parietal cortex

74.09 ± 17.00

45.5%

89.45 ± 4.16

23

Late-onset AD

AD

80

Parietal cortex

85.83 ± 6.88

61.25%

89.39 ± 3.81

23

ADADb

AD

18

Parietal cortex

50.17 ± 12.03

37.5%

86.06 ± 4.22

23

Controls

None

11

Parietal cortex

85.01 ± 9.06

45.5%

90.09 ± 1.87

23

PSP

PSP

84

Temporal cortex

73.96 ± 6.54

39.29%

NA

24

PSP

PSP

84

Cerebellum

73.95 ± 6.54

39.29%

NA

24

Controls

None

80

Temporal cortex

82.55 ± 8.80

48.75%

NA

24

Controls

None

79

Cerebellum

82.67 ± 8.11

49.37%

NA

24

  1. aMean ± standard deviation
  2. bPSEN1 A79V, N135S, I143T, H163R, S170F, G206A, G217R, L226R, I229F, S290C, T245P, C410Y, A431E
  3. NA not available