Table 5 Top-5 Genome-wide SNP × SZ interactions for brown module eigengenes for dopamine-stimulated data

From: Dopamine perturbation of gene co-expression networks reveals differential response in schizophrenia for translational machinery

SNP

Chrom.

Position (bp)a

MAb

Gene/ncRNA (Distance)

Beta (SE)

P SNP a SZ c

P PGC d

rs10497316

2

167,121,310

T

XIRP2 e

0.020 (0.0039)

3.8 × 10−7

0.98

rs17076524

6

146,985,464

T

STXBP5-AS1

0.018 (0.0036)

9.6 × 10−7

0.050

rs764113

7

109,040,240

A

AC004014.3 (88 kb)

−0.012 (0.0026)

1.8 × 10−6

0.0043

rs12540954

7

109,047,522

T

AC004014.3 (95 kb)

−0.012 (0.0026)

1.9 × 10−6

0.0050

rs10953591

7

109,048,681

C

AC004014.3 (96 kb)

−0.012 (0.0026)

2.7 × 10−6

0.0048

  1. aBased on human reference assembly GRCh38.p7
  2. bMinor allele
  3. cFor the P-values presented here, FDR (Benjamini-Hochberg method) = 0.18
  4. dGWAS P-values for SZ status as reported by the SZ Working Group of the Psychiatric Genomics Consortium (PGC), involving up to 36,989 SZ cases and 113,075 controls8
  5. eIn a recent gene-based association study of rare loss-of-function variants conducted by UK10K Consortium on whole-exome sequences of 4264 SZ cases, 9343 controls, and 1077 trios, the gene XIRP2 yielded the strongest association with SZ status (P = 3.5 × 10−5)37
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