Fig. 5: Impaired cognitive functioning in SAPAP4-deficient mice.
From: Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice
a During both days of the spontaneous alternation test, Dlgap4+/+ mice exhibited higher percentages of alternations than expected by chance (50%, indicated by dotted line; ##p < 0.01, Wilcoxon signed rank test) and as compared to Dlgap4geo/geo mice (*p < 0.5 and **p < 0.01, Mann–Whitney test). b The average time to perform a transition increased from day 1 and day 2 in Dlgap4+/+, but not Dlgap4geo/geo mice (§§§p < 0.001 Newman–Keuls post-hoc test after mixed two-way ANOVA) and was lower in Dlgap4geo/geo compared to Dlgap4+/+ mice (**p < 0.01 and ***p < 0.001, Newman–Keuls post-hoc test after mixed two-way ANOVA). c Impaired spatial learning in Dlgap4geo/geo mice as indicated by the increased escape latencies during the learning trials of the water maze test (***p < 0.001, effect of genotype after mixed two-way ANOVA). d–f During the probe trial of the water maze test, Dlgap4geo/geo mice spent less time in the target quadrant (d ***p < 0.001, Newman–Keuls post-hoc test after mixed two-way ANOVA) and swam at longer distances from the platform compared to Dlgap4+/+ mice (e ***p < 0.001, unpaired t-test). However, mice of both genotypes swam at the appropriate distance from the maze wall in order to find the platform (f the entire area with a platform to wall distance identical to the respective distance during the learning trials is displayed in grey). Simple vertical lines represent SEM. All experiments were performed with 11 adult male mice/genotype (cohort 1). For more details see text
