Table 2 The association between midlife serum high-density lipoprotein cholesterol (HDL-C) levels and mild cognitive impairment (MCI) by multiple imputations using chained equations (n = 1114, m = 100)

From: The association between midlife serum high-density lipoprotein and mild cognitive impairment and dementia after 19 years of follow-up

 

HDL-C levels (mmol/l)a

 

<1.29

1.29–1.50

1.53–1.76

≥1.78

P for trend

MCI

No. (Events)b

175 (69)

156 (62)

169 (60)

151 (34)

 

Model 1c OR (95% CI)

Reference

0.90 (0.61–1.33)

0.80 (0.53–1.21)

0.49** (0.31–0.78)

0.004

Model 2d OR (95% CI)

Reference

0.90 (0.61–1.35)

0.79 (0.52–1.22)

0.48** (0.29–0.79)

0.005

Model 3e OR (95% CI)

Reference

0.88 (0.59–1.33)

0.77 (0.50–1.20)

0.47** (0.28–0.79)

0.006

  1. aCholesterol levels are defined as quartiles in the complete case analysis
  2. bThe number of participants and events are stated as per the complete case analysis
  3. cModel 1 is adjusted for age, sex, and education
  4. dModel 2 is additionally adjusted for alcohol consumption, smoking, and body mass index
  5. eModel 3 is additionally adjusted for hypertension, history of diabetes mellitus, use of cholesterol lowering medications, low density lipoprotein cholesterol, and triglycerides
  6. **p < 0.01. Bold values denote statistically significant results
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