Table 3 Baseline characteristics according to midlife serum high-density lipoprotein cholesterol (HDL-C) quartiles for dementia analyses
Characteristics | Serum HDL-C quartile (mmol/l) | p valuea | Missing data (%) | |||
|---|---|---|---|---|---|---|
Quartile 1 (<1.29) | Quartile 2 (1.29–1.53) | Quartile 3 (1.55–1.81) | Quartile 4 (≥1.84) | |||
Proportion of all participants (%) | 15.5 | 14.0 | 14.5 | 14.3 | 41.7 | |
Age at screening [mean (years ± SD)] | 73.6 ± 5.8 | 73.1 ± 6.2 | 72.9 ± 5.3 | 73.2 ± 5.5 | n.s. | 0 |
Men (%) | 55.4 | 42.2 | 25.7 | 19.6 | <0.001 | 0 |
Education (%) | n.s. | 3.6 | ||||
Junior high school | 34.7 | 33.0 | 30.1 | 27.7 | ||
High school | 51.2 | 48.6 | 55.8 | 49.1 | ||
College/vocational school, University or Other | 14.1 | 16.7 | 14.2 | 23.2 | ||
Alcohol consumption (%) | 0.040 | 0 | ||||
<150 g ethanol per week | 78.5 | 73.4 | 88.5 | 80.4 | ||
≥150 g ethanol per week | 21.5 | 26.6 | 11.5 | 19.6 | ||
Smoking status (%) | <0.001 | 4.1 | ||||
Non-smoker | 65.3 | 67.0 | 83.2 | 83.0 | ||
Past smoker | 9.9 | 14.7 | 7.1 | 10.7 | ||
Current smoker | 24.8 | 18.4 | 9.7 | 6.3 | ||
Body mass index (kg/m2 ± SD) | 24.5 ± 2.7 | 23.6 ± 2.6 | 23.4 ± 2.6 | 22.2 ± 2.4 | <0.001 | 36.9 |
History of diabetes (%) | 5.0 | 1.8 | 1.8 | 0 | n.s. | 0 |
Hypertensionb (%) | 28.1 | 27.5 | 27.4 | 17.0 | n.s. | 36.9 |
Using cholesterol lowering medication (%) | 0 | 0.9 | 2.7 | 2.7 | n.s. | 0 |
Triglycerides [mean (mmol/l ± SD)] | 1.8 ± 0.9 | 1.3 ± 0.6 | 1.2 ± 0.6 | 1.0 ± 0.5 | <0.001 | 37.4 |
LDL-C [mean (mmol/l ± SD)] | 3.2 ± 0.7 | 3.2 ± 0.8 | 3.4 ± 0.9 | 3.0 ± 0.7 | 0.0019 | 38.3 |
