Table 4 The association between midlife serum high-density lipoprotein cholesterol (HDL-C) levels and dementia by multiple imputations using chained equations (n = 781, m = 100)

From: The association between midlife serum high-density lipoprotein and mild cognitive impairment and dementia after 19 years of follow-up

 

HDL-C levels (mmol/l)a

 
 

<1.29

1.29–1.53

1.55–1.81

≥1.84

P for trend

Dementia

No. (Events)b

121 (15)

109 (4)

113 (3)

112 (7)

 

Model 1c OR (95% CI)

Reference

0.34* (0.12–0.96)

0.33 (0.11–1.02)

0.45 (0.17–1.19)

n.s.

Model 2d OR (95% CI)

Reference

0.32* (0.11–0.93)

0.33 (0.11–1.04)

0.41 (0.14–1.18)

n.s.

Model 3e OR (95% CI)

Reference

0.34 (0.11–1.03)

0.38 (0.11–1.23)

0.40 (0.12–1.31)

n.s.

  1. n.s. = non-significant
  2. aCholesterol levels are defined as quartiles in the complete case analysis
  3. bThe number of participants and events are stated as per the complete case analysis
  4. cModel 1 is adjusted for age, sex, and education
  5. dModel 2 is additionally adjusted for alcohol consumption, smoking, and body mass index
  6. eModel 3 is additionally adjusted for hypertension, history of diabetes mellitus, use of cholesterol lowering medications, low density lipoprotein cholesterol, and triglycerides
  7. *p < 0.05. Bold values denote statistically significant results
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