Fig. 3: Scatterplot of diathesis-stress interactions on depression score.
From: A validation of the diathesis-stress model for depression in Generation Scotland
Interactions with PRS at which nominally significant GxE effects were detected in (a) full cohort (p-threshold = 0.01) and (b) in women (p-threshold = 1 × 10–5) are shown. At bottom, the remaining samples (i.e., full cohort, women or men) at same p-threshold are shown for comparison. The X-axis represents the direct effect of PRS (standard deviation from the mean) based on (a) p-threshold = 0.01 and (b) p-threshold = 1 × 10–5, using the total number of SLE reported by each participant (dot) as environmental exposures at three SLE levels represented by colors. Blue: 0 SLE, “no stress”, n = 1 833/1 041/792; green: 1 or 2 SLE, “low stress”, n = 2 311/1 459/852; red: 3 or more SLE, “high stress”, n = 775/490/285; in the full cohort, women and men, respectively. Y-axis reflects the depression score standardized to mean of 0 and standard deviation of 1. Lines represent the increment in risk of depression at a certain degree of “stress” dependent on a genetic predisposition ( = diathesis)
