Table 1 Description of data sets assembled for consensus analysis. (a) Gene expression cohorts. (b) DNA methylation cohorts

From: Meta-analysis of expression and methylation signatures indicates a stress-related epigenetic mechanism in multiple neuropsychiatric disorders

(a)

    

Data set

Disease

Platform

Brain region

Sample size (control:case)

Ryan et al.55 [GSE5388]

Bipolar disorder

HG-U133A

BA9

31:30

Maycox et al.56 [GSE17612]

Schizophrenia

HG-U133-P2

BA10

23:28

Zhang et al.57; Zheng et al.58 [GSE20168]

Parkinson’s

HG-U133A

BA9

15:14

Narayan et al.59 [GSE21138]

Schizophrenia

HG-U133-P2

BA46

29:30

SMRI AltarC

Multiplea

HG-U133A

BA46/10

11:33

SMRI Bahn

Multipleb

HG-U133A

BA46

33:65

Chang et al.60 [GSE54567/54568/54570]

Major depression

HG-U133A

BA9

42:42

(b)

    

Data set

Disease

Platform

Brain region

Sample size (control:case)

Xu et al.25 [GSE49393]

Alcoholism

HM450

BA9

23:23

Lunnon et al.61 [GSE59685]

Alzheimer’s

HM450

PFC

24:56

Wockner et al.62 [GSE61107]

Schizophrenia

HM450

PFC

24:24

Pidsley et al.63 [GSE61380/61431]

Schizophrenia

HM450

BA9

38:38

Jaffe et al.64 [GSE74193]

Schizophrenia

HM450

BA46/9

240:191

Smith et al.65 [GSE80970]

Alzheimer’s

HM450

PFC

68:74

  1. BA Brodmann area, HM450 Illumina Infinium Human Methylation 450 Beadchip, PFC prefrontal cortex (for which Brodmann areas not specified), HG-U133A Affymetrix Human Genome U133A Array, HG-U133-P2 Affymetrix Human Genome U133 Plus 2.0 Array, SMRI Stanley Medical Research Institute
  2. a. Cases consist of 11 bipolar disorder, 11 major depressive disorder, and 11 schizophrenia patients
  3. b. Cases consist of 31 bipolar disorder and 34 schizophrenia patients
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