Fig. 2: Losartan rescues extinction consolidation impairment in OVX females.
From: Estradiol modulation of the renin–angiotensin system and the regulation of fear extinction
a No group differences in freezing were evident during fear conditioning in ovariectomized (OVX) or gonadally intact sham-operated (Sham) rats. b A trend for increased freezing was found in OVX females during extinction training compared with Sham proestrus females. c OVX females exhibited significantly greater freezing compared with sham females during extinction recall, indicating that extinction consolidation is disrupted in the OVX females. d No group differences in freezing were evident during fear conditioning in the two groups of OVX rats. e OVX females treated with 10 mg/kg losartan spent significantly less time freezing during the extinction session compared with vehicle-treated females; however, no significant differences in freezing were observed between groups during the last CS block. f Freezing was significantly reduced in OVX losartan-treated females during extinction recall compared with the OVX vehicle-treated group. *p < 0.05; #p < 0.10
