Fig. 5: Perinatal exposure to EFV affects serotonergic (but not catecholaminergic) innervation of the M1. | Translational Psychiatry

Fig. 5: Perinatal exposure to EFV affects serotonergic (but not catecholaminergic) innervation of the M1.

From: Neurodevelopmental and behavioral consequences of perinatal exposure to the HIV drug efavirenz in a rodent model

Fig. 5

a, b Camera lucida drawings of immunostaining for a 5-HT+ and b TH+ fibers in deep and superficial layers of the M1 in EFV-exposed and Ctrl-exposed brains (n = 7 per group for TH+ and n = 5 per group for 5-HT+). c Significant increase in 5-HT+ fiber length in bin2 and 6 in the EFV group. d, e Significant increase in 5-HT+ fiber length, but no difference in TH+ fiber length in the total M1 area of the EFV-exposed group. Data show mean ( ± SEM) number of fibers, *p < 0.05 analyzed using one-way ANOVA. 5-HT serotonin, Ctrl vehicle, EFV efavirenz, TH tyrosine hydroxylase, ANOVA analysis of variance

Back to article page