Fig. 3: Distribution of proinflammatory cytokine levels depending on rs174547 of FADS genotype and frequency of oil-rich fish intake.

a Plot of plasma tumor necrosis factor alpha (TNFα) level by rs174547 of FADS genotype in the total cohort (N = 155), indicating that the C allele is associated with greater frequency of elevated TNFα level (>2.84 pg/mL, indicated by the horizontal dotted bar). b Plot of plasma interleukin (IL)-6 level by oil-rich fish intake in the total cohort (N = 155), indicating that individuals who consumed oil-rich fish less frequently tended to be more likely to have high IL-6 level (>25.0 pg/mL, indicated by the horizontal dotted bar). c) Plot of IL-6 level by oil-rich fish intake in the patients (N = 65). There was no patient who had high IL-6 level among those who consumed oil-rich fish two or more times per week