Table 1 The AD sets show varying degrees of overlap

From: Drug repurposing for Alzheimer’s disease based on transcriptional profiling of human iPSC-derived cortical neurons

 

AD

BRAAKmild

COGI

5xFAD

3xTG

AD

11.26 ± 0.45

−1.81 ± 0.38

13.34 ± 1.08

3.38 ± 0.33

0.05 ± 0.11

BRAAKmild

 

4.43 ± 1.00

−1.03 ± 0.83

−0.35 ± 0.34

−0.04 ± 0.20

COGI

  

15.10 ± 3.47

3.09 ± 0.70

0.26 ± 0.23

5xFAD

   

13.23 ± 1.67

0.46 ± 0.21

3xTG

    

−0.06 ± 0.25

  1. The overt AD profile set is highly correlated with the cognitive decline profiles. There is a degree of overlap with the 5xFAD profiles but poor agreement with the mild BRAAK and 3xTG animal profiles. The 3xTG profile set is conspicuous for not being internally consistent or having significant overlap with the other AD sets. The numbers in the table correspond to the average Z score across pairs in the sets, excluding correlations of profiles with themselves
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