Fig. 2: Analysis of the HLA-DRB9 locus.
From: Chromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia
a The H3K4me3-marked open chromatin peak at the distal 3′-region of HLA-DRB9 was upregulated in neurons from individuals with schizophrenia (indicated by a star); peak genomic coordinates are chr6:32427120–32428371. b The transcription activity(Illumina BodyMap 2.0 data) and chromatin state62 suggest common activity of this locus in the testis. c A cluster of significant variations from GWAS data for schizophrenia next to the peak (18). The log Y-scale represents reported nominal P-values for variants (36,989 cases and 113,075 controls). Bottom panel: the SNPs rs9268830 (inside the peak) and rs9268895 (the most significant SNP associated with schizophrenia in GWAS data) (19). SZ samples are marked with S prefix, control individuals are marked with C prefix. Red and blue colors indicate SZ and CTRL, respectively
