Table 1 Demographics, substance use and PANSS/childhood trauma scores

From: The relationship between childhood trauma, dopamine release and dexamphetamine-induced positive psychotic symptoms: a [11C]-(+)-PHNO PET study

 

Participants N = 24

Female

11

Male

13

Age

23.41 (4.20)

Tobacco smokers, (n)

2

Tobacco use (cigarettes/day), mean (SD)

 

aAlcohol use (UK alcohol units/week), mean (SD)

4.83 (4.8)

Current cannabis

0

Past cannabis 0/1/2/3/4

15/4/4/1/0

Past cocaine use 0/1/2/3/4

22/1/1/0/0

Past amphetamine use 0/1/2/3/4

24/0/0/0/0

Past ecstasy use 0/1/2/3/4

19/5/0/0/0

Past morphine use 0/1/2/3/4

24/0/0/0/0

Past heroine use 0/1/2/3/4

24/0/0/0/0

Dexamphetamine PANSS positive score baseline, mean (SD)

7.00 (0)

Dexamphetamine PANSS positive score 60 min, mean (SD)

8.33 (1.55)

Dexamphetamine PANSS positive score 120 min, mean (SD)

8.25 (1.22)

Dexamphetamine PANSS positive score 275 min, mean (SD)

8.21 (1.50)

Placebo PANSS positive score baseline, mean (SD)

7.00 (0)

Placebo PANSS positive score 60 min, mean (SD)

7.14 (0.36)

Placebo PANSS positive score 120 min, mean (SD)

7.19 (0.40)

Placebo PANSS positive score 275 min, mean (SD)

7.14 (.48)

CTQ, mean (SD)

36.7 (19.73)

  1. For drug use, categories of 0/1/2/3/4/5 indicate never used/very occasional or experimental use/occasional or monthly use/moderate or weekly use/severe or daily use, respectively
  2. CTQ Childhood Trauma Questionnaire, d-amph dexamphetamine, D2/3R dopamine D2/3 receptor
  3. aUK alcohol unit = 10 ml ≅ 7.88 g alcohol
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