Table 2 Characteristics of included child and adolescent studies.

From: Pharmacological prevention and early treatment of post-traumatic stress disorder and acute stress disorder: a systematic review and meta-analysis

 

Country

Trauma sample

Pharmacotherapy

Timing after trauma

Comparator

n

PTSD/ASD outcome

Follow up

Nugent*

USA

Injury

Propranolol

<12 h

Placebo

20

PTSD Incidence & Severity (CAPS-CA)

6 weeks

Rosenberg et al.*

USA

Burns

Propranolol

<2 days

Standard therapy

197

PTSD Incidence (MAGIC)

7 years

Robert et al.*

USA

Burns

Imipramine

36 days

Chloral hydrate

25

ASD Severity (Clinical Interview)

36 days

  1. *Included in meta-analysis, PTSD, post-traumatic stress disorder, ASD, acute stress disorder, n, number of participants included at final assessment,
  2. CAPS-CA, clinician administered PTSD scale for children & adolescents, MAGIC, Missouri Assessment of Genetics Interview for Children,
  3. PTSD Section, DICA, diagnostic interview for children & adolescents