Table 1 Sociodemographic and clinical characteristics.
From: Basal and LPS-stimulated inflammatory markers and the course of individual symptoms of depression
Whole sample | LPS-induced subsample | |
|---|---|---|
n = 2872 | n = 1229 | |
Age in years (mean, SD) | 41.9 (13.0) | 42.8 (12.7) |
Female (%) | 66.5 | 65.6 |
North-European etnicity (%) | 94.9 | 94.8 |
BMI (mean, SD) | 25.6 (5.0) | 25.7 (5.0) |
Smoking status (%) | ||
Never smoker | 28.0 | 29.0 |
Former smoker | 33.6 | 34.2 |
Current smoker | 38.4 | 36.8 |
Education level (%) | ||
Elementary or lower | 6.49 | 6.4 |
Secondary education | 58.2 | 56.7 |
College or university | 35.4 | 36.9 |
Sickness prior to interview (%) | 27.9 | 30.1 |
Chronic somatic disease, yes (%) | 40.4 | 44.3 |
Anti-inflam. med., yes (%) | 4.9 | 3.1 |
MDD, yes (%) | 35.4 | 28.8 |
Minor depression, yes (%) | 2.8 | 2.1 |
Dysthymia, yes (%) | 9.3 | 10.4 |
Anxiety disorder, yes (%) | 43.6 | 44.4 |
No Disorder (%) | 46.1 | 46.3 |
No lifetime disorder (%) | 34.1 | 36.3 |
Total score IDS at baseline (SD) | 21.184 (14.6) | 20.86 (14.6) |
Antidepressants | ||
TCA (%) | 3.7 | 2.9 |
SSRI (%) | 16.8 | 16.5 |
Other (%) | 5.5 | 5.6 |
No AD (%) | 75.5 | 75.9 |
Inflammatory markers (mean, sd) | ||
TNF-α (pg/ml) | 1.09 (1.41) | |
IL-6 (pg/ml) | 1.55 (13.5) | |
CRP (mg/L) | 2.82 (5.12) | |
Inflammatory markers after LPS induction (mean, sd) | ||
IFN-ƴ (pg/ml) | 12.80 (10.8) | |
IL-10 (pg/ml) | 300.28 (294.9) | |
IL-18 (pg/ml) | 262.39 (91.9) | |
IL-2 (pg/ml) | 10.06 (5.0) | |
IL-6 (ng/ml) | 27.36 (15.6) | |
IL-8 (ng/ml) | 12.02 (7.7) | |
MCP-1 (ng/ml) | 1.72 (1.1) | |
MIP-1α (ng/ml) | 19.38 (12.0) | |
MIP-1β (ng/ml) | 245.52 (123.3) | |
MMP-2 (pg/ml) | 72.13 (19.3) | |
TNF-α (ng/ml) | 3.19 (2.0) | |
TNF-β (pg/ml) | 324.21 (126.6) | |
