Table 3 Two-sample MR analysis results for chronic pain and sleep disturbance.
Outcome | #SNP | Mendelian randomization | IVW regression test for variant heterogeneity | MR Egger test for directional horizontal pleiotropy | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
B | SE | p-value | Q | df | p-value | Egger intercept | SE | p-value | |||
Sleep disturbance | 35 | IVW test | 0.670 | 0.087 | 1.65 × 10−14 | 69.879 | 34 | 2.81 × 10−4 | −0.00042 | 0.0066 | 0.95 |
MR Egger | 0.696 | 0.406 | 0.096 | ||||||||
Weighted median | 0.490 | 0.097 | 3.88 × 10−7 | ||||||||
MR-PRESSO | 0.698 | 0.092 | 6.58 × 10−9 | ||||||||
Contamination mixture | 0.580 | 0.120 | 1.31 × 10−6 | ||||||||
Chronic pain | 13 | IVW test | 0.205 | 0.042 | 9.69 × 10−7 | 50.322 | 12 | 1.23 × 10−6 | 0.00944 | 0.0043 | 0.051 |
MR Egger | −0.030 | 0.114 | 0.794 | ||||||||
Weighted median | 0.135 | 0.038 | 3.33 × 10−4 | ||||||||
MR-PRESSO | 0.205 | 0.042 | 3.67 × 10−4 | ||||||||
Contamination mixture | 0.370 | 0.038 | 5.89 × 10−5 | ||||||||
