Fig. 1: Microglial alterations in the dentate gyrus (DG) of HAB mice.
From: Neuroinflammatory alterations in trait anxiety: modulatory effects of minocycline
Hyperanxious HAB mice show significantly enhanced Iba1+ cell density, Iba1+ cell area average, and percentage of coverage by Iba1+ cells of the dorsal DG, compared to NAB controls (a). Representative images of Iba1 (red) and DAPI (blue) staining in the DG of HAB and NAB mice, inset is microglia size example (b) scale bar 100μm. Iba1+ CD68+ cell density is enhanced in the granular cell layer of the DG in HAB (a). Representative images of Iba1 (red) and CD68 (green) staining in the DG of HAB and NAB mice (c), scale bar 50 μm. Data are presented as mean ± SEM. n = 7–11. *p < 0.05, **p <0.01, ***p < 0.001 vs. NAB (Student’s t - test).
