Fig. 4: Impact of local application of into the dentate gyrus (DG) on anxiety-like behavior of HAB mice.
From: Neuroinflammatory alterations in trait anxiety: modulatory effects of minocycline
Experimental timelines, shorter period (5 d) (a) and longer periods (11 d) (b) of minocycline infusions. Following 5 days of intra-DG minocycline or saline daily infusions, HAB groups showed no significant differences in the light/dark test (c). Following 10 days of intra-DG minocycline daily infusions, HAB displayed increased time spent in, entries to, and distance traveled in, the light arena of the light/dark test (d), compared to intra-DG saline HAB. Data are presented as mean ± SEM. n = 7–11, *p < 0.05, **p < 0.01, ***p < 0.001 (Student’s t-test).
