Fig. 5: Impact of local application of minocycline into the dentate gyrus (DG) on Iba-1 density in HAB mice.
From: Neuroinflammatory alterations in trait anxiety: modulatory effects of minocycline
Schematic illustration of the sites of DG hits (a). Following 5 days of intra-DG minocycline or saline daily infusions, HAB groups showed no significant differences in the Iba-1 density (b). Following 10 days of intra-DG minocycline daily infusions, HAB showed reduced Iba-1 density (b). Representative images showing Iba-1+ cells in the DG following long-term intra-DG vehicle/ minocycline administration (c). Data are presented as mean ± SEM. n = 7–11, *p < 0.05 (Student’s t-test).
