Fig. 4: Effects of test drugs on spontaneous locomotion.

Locomotor activity expressed as the mean (±SEM) is shown for total distance traveled in meters (m) across a 1-h session. Rats were pretreated 30min prior to the start of the session with either vehicle, SB224289 (10 mg/kg, s.c.) or BRL15572 (0–3.0 mg/kg, i.p.). Rats in the SB224289 experiment received a second pretreatment of either vehicle or zolmitriptan (5.6 mg/kg, s.c.) 15min later. There were no main effects nor interactions; data are collapsed across male (n = 6) and female (n = 7) rats.