Table 2 Mean baseline, 6, and 12-month postoperative neuropsychological scores (n = 10 subjects).

From: Examining cognitive change in magnetic resonance-guided focused ultrasound capsulotomy for psychiatric illness

 

Baseline

6 months

12 months

Decline ≥ 2 SD

Improvement ≥ 2 SD

B-12mos

B-6mos

B-12mos

B-6mos

CVLT total recalla

53.3 (8.2)

55 (7.0)

52.7 (12.2)

0

0

0

0

CVLT delayed free recallc

0.0 (0.8)

−0.1 (1.0)

0.3 (0.8)

0

0

0

0

CVLT delayed cued recallc

−0.4 (1.4)

0.2 (0.8)

0.2 (0.8)

0

0

1 (pt8)

1 (pt8)

CVLT delayed recognition discriminationc

−0.2 (1.8)

0.1 (0.7)

0.2 (0.8)

0

0

1 (pt8)

1 (pt8)

BVMT-R immediate recalla

41.1 (16.1)

47.6 (11.2)

51.7 (13.0)*

0

0

3 (pt1,6,10)

1 (pt10)

BVMT-R delayed recalla

44.5 (16.8)

51.1 (9.4)

53.4 (11.4)*

0

0

1 (pt3)

0

Oral SDMTc

−1.0 (0.9)

−0.5 (0.9)*

−0.6 (1.0)

0

0

0

0

D-KEFS Sorting Test: correct sortsb

9.8 (1.8)

12.5 (1.9)*

13.4 (3.1)*

0

0

4 (pt2,3,6,8)

0

D-KEFS Sorting Test: description scoreb

10.3 (2.5)

12.4 (2.2)*

13.1 (3.3)*

0

0

1 (pt8)

1 (pt8)

IGT total scorea

45.5 (8.9)

47.0 (9.0)

49.8 (7.0)

0

0

1 (pt4)

0

FrSBe total scorea

73.9 (14.0)

66.1 (14.7)

63.5 (17.0)*

0

0

2 (pt3,6)

1 (pt1)

FrSBe disinhibition scorea

57.8 (20.4)

52.6 (17.7)

50.4 (18.6)

0

0

3 (pt3,6)

2 (pt3,6)

FrSBe apathy scorea

88.9 (17.8)

79.6 (18.2)*

76.4 (25.3)*

0

0

2 (pt3,6)

1 (pt1)

FrSBe dysexecutive scorea

68.9 (14.1)

62.7 (8.6)

60.6 (12.6)

0

0

2 (pt3,6)

1 (pt1)

  1. Scores were standardized with published normative data, and reported in the following format: a T-Score (mean of 50, SD of 10); b Scaled Score (mean of 10, SD of 3); c Z-Score (mean of 0; SD of 1).
  2. B-12mos change from baseline to 12 months, B-6mos change from baseline to 6 months, Pt patient, CVLT California Verbal Learning Test, BVMT-R Brief Visuospatial Memory Test-Revised, SDMT Symbol Digit Modalities Test, FrSBe Frontal Systems Behavior Scale—self-version (lower scores represent fewer behavioral symptoms), IGT Iowa Gambling Task.
  3. *Denotes p < 0.05 on a Wilcoxon signed rank test in comparison to baseline.
  4. Note that 7/10 patients completed the IGT at 6 months, and 9/10 patients completed the IGT at 12 months.