Fig. 3: Developmental trajectories of radial diffusivity (RD) in patients with 22q11.2DS and controls. | Translational Psychiatry

Fig. 3: Developmental trajectories of radial diffusivity (RD) in patients with 22q11.2DS and controls.

From: Identifying neurodevelopmental anomalies of white matter microstructure associated with high risk for psychosis in 22q11.2DS

Fig. 3

RD metrics mostly followed quadratic decreasing trajectories in 22q11.2DS (red) and controls (blue). Similar to other diffusion measures, age × group interactions were absent and both groups therefore displayed identically shaped developmental curves. Group differences were evident in a majority of white matter tracts, with systematic reductions of RD in individuals with 22q11.2DS. Tracts with significant group differences are highlighted in orange in plot titles and in the central figure. The significance threshold was set at p < 0.05. All results were corrected for multiple comparisons using the FDR method. lh left hemisphere, rh right hemisphere, FMAJ forceps major, FMIN forceps minor, ATR anterior thalamic radiation, CAB cingulum–angular bundle, CCG cingulum–cingulate bundle, CST corticospinal tract, ILF inferior longitudinal fasciculus, SLFP superior longitudinal fasciculus–parietal bundle, SLFT superior longitudinal fasciculus–temporal bundle, UNC uncinate fasciculus.

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