Fig. 4: Developmental trajectories of fractional anisotropy (FA) in patients with 22q11.2DS and controls. | Translational Psychiatry

Fig. 4: Developmental trajectories of fractional anisotropy (FA) in patients with 22q11.2DS and controls.

From: Identifying neurodevelopmental anomalies of white matter microstructure associated with high risk for psychosis in 22q11.2DS

Fig. 4

FA metrics followed increasing quadratic or linear developmental curves in 22q11.2DS (red) and controls (blue). Age × group interaction effects were again not significant, revealing parallel trajectories in both groups. Group differences were visible in a number of tracts, where FA was systematically increased in 22q11.2DS. Tracts with significant group differences are highlighted in orange in plot titles and in the central figure. The significance threshold was set at p < 0.05. All results were corrected for multiple comparisons using the FDR method. lh left hemisphere, rh right hemisphere, FMAJ forceps major, FMIN forceps minor, ATR anterior thalamic radiation, CAB cingulum–angular bundle, CCG cingulum–cingulate bundle, CST corticospinal tract, ILF inferior longitudinal fasciculus, SLFP superior longitudinal fasciculus–parietal bundle, SLFT superior longitudinal fasciculus–temporal bundle, UNC uncinate fasciculus.

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