Fig. 2: Brain response to social stimuli associated with the novel T-PRS and the PGC-PRS. | Translational Psychiatry

Fig. 2: Brain response to social stimuli associated with the novel T-PRS and the PGC-PRS.

From: Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms

Fig. 2

Higher levels of T-PRS were associated with lower activity in the LV1 clusters during the neutral faces condition in women and higher activity in the LV1 clusters during the emotional faces and shapes conditions in men (A). Higher levels of PGC-PRS were associated with lower activity in the LV1 clusters during the Neutral faces condition in women (B). Error bars represent 95% confidence intervals based on the bootstrapping distribution, which can be asymmetrical. Specifically, higher levels of T-PRS were more strongly associated with lower activity in frontal regions, including the mid-frontal (C) and frontal superior medial (D), and caudate (E) and higher levels of PGC-PRS were associated with low activity in insula (F) and mid-occipital (G). These clusters survived the 2.5 bootstrap ratio (corresponding to 95% reliability) and were greater than 20 voxels.

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