Fig. 1: Behavioral syndrome induced by ketamine in WT and GluN2CKO mice of both genders. | Translational Psychiatry

Fig. 1: Behavioral syndrome induced by ketamine in WT and GluN2CKO mice of both genders.

From: Involvement of NMDA receptors containing the GluN2C subunit in the psychotomimetic and antidepressant-like effects of ketamine

Fig. 1

Effects of ketamine (10 and 30 mg/kg) in male (♂) and female (♀) WT and GluN2CKO mice on: a total distance (percentage from saline-treated mice); b peripheral distance (percentage from saline-treated mice); c central distance (percentage from saline-treated mice); d rearings (percentage from saline-treated mice); e hindlimb abduction; f falls and g circling. Male WT saline (n = 15); male GluN2CKO saline (n = 16); female WT saline (n = 18); female GluN2CKO saline (n = 17); male and female WT and GluN2CKO ketamine 10 mg/kg and male GluN2CKO ketamine 30 mg/kg (n = 8); male WT ketamine 30 mg/kg (n = 10); female WT and GluN2CKO ketamine 30 mg/kg (n = 9). *p < 0.05, **p < 0.01 vs. saline; ##p < 0.01 vs. WT (Dunn’s or Newman–Keuls post hoc tests).

Back to article page