Fig. 2: Tail suspension test and microdyalisis study in WT and GluN2CKO mice of both genders. | Translational Psychiatry

Fig. 2: Tail suspension test and microdyalisis study in WT and GluN2CKO mice of both genders.

From: Involvement of NMDA receptors containing the GluN2C subunit in the psychotomimetic and antidepressant-like effects of ketamine

Fig. 2

a Effects of ketamine (10 and 30 mg/kg) in male (♂) and female (♀) WT and GluN2CKO mice in the tail-suspension test (TST). Data are expressed as percentage of immobility from saline-treated mice. Male WT saline (n = 14); male GluN2CKO saline (n = 15); female WT saline (n = 16); female GluN2CKO saline (n = 18); male WT and GluN2CKO ketamine 10 and 30 mg/kg (n = 8); female WT ketamine 10 mg/kg (n = 9); female WT ketamine 30 mg/kg (n = 11); female GluN2CKO ketamine 10 mg/kg (n = 7); female GluN2CKO ketamine 30 mg/kg (n = 12). b Time course of extracellular levels of serotonin (5-HT) in the medial prefrontal cortex (mPFC) after saline or 30 mg/kg of ketamine (Ket30) administration in male and female WT and GluN2CKO mice. Male WT and GluN2CKO saline and male GluN2CKO Ket30 (n = 9); male WT Ket30 (n = 8); female WT saline (n = 13); female GluN2CKO saline (n = 14); female WT and GluN2CKO Ket30 (n = 11). c Time course of extracellular levels of glutamate (Glu) in the mPFC after saline or 30 mg/kg of ketamine (Ket30) administration in male and female WT and GluN2CKO mice. Male WT and GluN2CKO saline and Ket30 (n = 9); female WT saline (n = 12); female GluN2CKO saline (n = 14); female WT Ket30 (n = 11); female GluN2CKO Ket30 30 (n = 13). Microdialysis data are expressed as percentage of four basal values (fractions 1–4). The values are expressed as mean ± SEM. The arrow represents the time of IP injection of saline or ketamine. Dialysate fractions were 30 min each. *p < 0.05, **p < 0.01 vs. saline; #p < 0.05, ##p < 0.01 vs. WT (Newman–Keuls post hoc test).

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