Fig. 3: Ketamine-induced c-fos brain expression in male WT and GluN2CKO mice. | Translational Psychiatry

Fig. 3: Ketamine-induced c-fos brain expression in male WT and GluN2CKO mice.

From: Involvement of NMDA receptors containing the GluN2C subunit in the psychotomimetic and antidepressant-like effects of ketamine

Fig. 3

c-fos mRNA expression for male (♂) WT and GluN2CKO mice after saline or ketamine (30 mg/kg) administration. Upper, intermediate, and deep layers of primary and secondary motor cortices (upper M1–M2, mid M1–M2, and deep M1–M2, AP: +2.10), medial prefrontal cortex (mPFC, AP: +2.10), cingulate cortex (Cg, AP: +1.18), caudate-putamen nuclei (CPu, AP: +1.18), nucleus accumbens (NAc, AP: +1.18), piriform cortex (Pir, AP: +1.18), retrosplenial cortex (RSC, AP: −1.70), hippocampus (HPC, AP: −1.70), habenula (Hb, AP: −1.70), paraventricular thalamic nucleus (PV, AP: −1.70), mediodorsal thalamic nucleus (MD, AP: −1.70), intermediodorsal thalamic nucleus (IMD, AP: −1.70), centromedial thalamic nucleus (CM, AP: −1.70), paracentral thalamic nucleus (PC, AP: −1.70), ventrolateral thalamic nucleus (VL, AP: −1.70), reuniens, and rhomboid nuclei of the thalamus (Re/Rh, AP: −1.70), reticular nucleus (RtN, AP: −1.70), dorsal raphe (DR, AP: −4.60), crus 1 of the ansiform lobule (Crus1, AP: −6.00), cerebellar simple lobule (Sim, AP: −6.00), lobules 4 and 5 of the cerebellar vermis (4/5Cb, AP: −6.00) and vestibular nucleus (Ve, AP: −6.00). n = 5 in all groups, except for n = 4 in WT ketamine groups in Cg, CM, Crus1, Sim, 4/5Cb, Ve; and n = 4 in GluN2CKO saline group in IMD. **p < 0.01 vs. saline; #p < 0.05, ##p < 0.01 vs. WT (Newman–Keuls post hoc test).

Back to article page