Table 2 CYP2D6 and CYP2C19 allele frequencies per major geographical region^a.

From: Meta-analysis of probability estimates of worldwide variation of CYP2D6 and CYP2C19

Region		CYP2D6*2	CYP2D6*4	CYP2D6*5	CYP2D6*10	CYP2D6*17	CYP2D6*29	CYP2D6*35	CYP2D6*41	CYP2D6*45	CYP2C19*2	CYP2C19*3	CYP2C19*17
Africa	M	0.25	0.10	0.04	0.03	0.19	0.09	0.01	0.04	0.07	0.17	0.00	0.23
	n	6815	7012	6796	6711	6631	5941	181	6206	153	9140	7189	5477
	SD	0.07	0.03	0.02	0.01	0.03	0.02	0.01	0.04	0.03	0.03	0.01	0.02
African Americans	M	0.20	0.08	0.04	0.04	0.19	0.06	0.00	0.03	0.03	0.18	0.00	0.22
	n	3911	4057	4057	3811	3811	3647	131	3648	252	3877	3877	3533
	SD	0.03	0.01	0.01	0.01	0.01	0.00	0.00	0.02	0.00	0.01	0.00	0.01
Americas	M	0.25	0.12	0.03	0.02	0.02	0.01	0.02	0.04	0.00	0.11	0.00	0.13
	n	18,065	19,802	18,571	18,580	16,018	15,496	8399	16,052	528	12,261	11,155	9091
	SD	0.08	0.05	0.02	0.03	0.03	0.02	0.02	0.03	0.00	0.04	0.01	0.04
Central/South East Asia	M	0.34	0.10	0.03	0.10	0.00	0.00	0.00	0.13		0.33	0.01	0.15
	n	10,523	12,393	10,573	11,180	9797	8700	10	8822		14,789	13,076	10,837
	SD	0.07	0.04	0.03	0.11	0.00	0.00	0.00	0.02		0.05	0.03	0.04
East Asia	M	0.13	0.00	0.05	0.49	0.00	0.00	0.00	0.02		0.30	0.07	0.02^b
	n	16,297	15,510	18,049	18,978	11,050	5234	3039	14,608		24,120	24,861	6756
	SD	0.03	0.01	0.01	0.08	0.00	0.00	0.00	0.01		0.05	0.03	0.01
Europe	M	0.36	0.18	0.03	0.02	0.00	0.00	0.06	0.08		0.15	0.00	0.23
	n	128,397	143,492	134,524	127,590	125,502	123,554	1040	125,303		180,615	130,396	170,889
	SD	0.08	0.04	0.01	0.02	0.01	0.01	0.01	0.03		0.02	0.00	0.02
Middle East	M	0.29	0.09	0.02	0.14	0.03	0.02		0.25		0.15	0.02	0.25
	n	1123	2902	1424	1816	1116	340		961		4768	3728	1903
	SD	0.11	0.06	0.01	0.11	0.03	0.01		0.09		0.08	0.04	0.06
Oceania	M	0.05	0.04	0.05	0.02	0.00	0.00		0.02		0.77	0.14	0.13
	n	279	361	361	361	301	62		122		5687	149	24
	SD	0.04	0.05	0.03	0.02	0.00	0.00		0.02		0.09	0.15	0.00
Total	M	0.32	0.15	0.03	0.07	0.01	0.01	0.02	0.07	0.02	0.18	0.01	0.21
	n	185,410	205,529	194,355	189,027	174,226	162,974	12,800	175,722	933	255,257	194,431	208,510
	SD	0.11	0.06	0.02	0.15	0.05	0.02	0.02	0.04	0.03	0.11	0.03	0.05

Bold = prevalence >0.05.
M mean, n number of genotyped subjects, SD standard deviation.
^aFor references, please see Supplemental Table 1.
^bFor this specific region, CYP2C19*17 is not part of the minimum set of alleles for reliable phenotype prediction, because with 2% it is less prevalent than 5% in this area. This means that studies from East Asia who only determined CYP2C19*2 and *3 are included in the meta-analysis.

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Table 2 CYP2D6 and CYP2C19 allele frequencies per major geographical region^a.

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