Table 2 Comparison of plasma GFAP between Aβ− and Aβ+ participants.

From: Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer’s disease

 

Aβ−

(95% CI)

Aβ+

(95% CI)

p

pa

All participants

n = 63

 

n = 33

   
 

151.42 ± 58.49

(129.66–173.18)

240.12 ± 124.88

(210.05–270.18)

7E−6

5.76E−7

SMC

n = 49

 

n = 25

   
 

152.73 ± 58.18

(126.35–179.11)

252.22 ± 137.75

(215.29–289.16)

b9E−6

4.8E−5

Non-SMC

n = 14

 

n = 8

   
 

146.83 ± 61.58

(112.06–181.60)

202.28 ± 63.81

(156.28–248.27)

0.059

0.020

  1. Plasma glial fibrillary acidic protein (GFAP) levels were compared between cognitively normal older adults with low brain Aβ load (Aβ−) and high brain Aβ load (Aβ+) using linear models. All participants were further categorised into subjective memory complainers (SMC, n = 74) and non-complainers (non-SMC, n = 22). Data are presented in mean ± SD in pg/mL. p values in bold font were considered as significant (p < 0.05).
  2. ap represents p values adjusted for age, sex, and APOE ε4 status.
  3. bRepresents p values obtained from natural log transformed GFAP concentrations to better approximate normality when required.
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