Table 2 Top 20 differentially methylated CpG sites resulting from the comparison between BPD+T patients (N = 49) and BPD-T patients and CTL (N = 91).

From: A genome-wide methylation study reveals X chromosome and childhood trauma methylation alterations associated with borderline personality disorder

CpG site

P value

Q value

B

Chr.

Chr. position

Gene

Gene region

cg15948871

9.09E−10

3.86E−04

10.57

6

31139620

POU5F1

TSS1500a

cg24915915

6.01E−08

1.15E−02

6.45

2

231799064

GPR55

IGRa

cg04511534

8.10E−08

1.15E−02

6.16

17

4463371

GGT6

Bodya

cg00253346

1.09E−07

1.16E−02

5.87

22

42324281

TNFRSF13C

TSS1500

cg05478172

3.07E−07

2.61E−02

4.86

12

47628981

FAM113B

Body

cg16465769

7.10E−07

5.03E−02

4.04

6

43266151

SLC22A7

1stExona

cg26529771

1.07E−06

6.20E−02

3.64

16

89260650

CDH15

Body

cg10030436

1.17E−06

6.20E−02

3.56

X

48755633

PQBP1

5′UTRb

cg07823755

1.36E−06

6.44E−02

3.40

2

234668355

UGT1A10

Body

cg07583088

1.73E−06

7.25E−02

3.17

16

1181617

 

IGR

cg20587394

1.88E−06

7.25E−02

3.09

12

54332209

HOXC13

TSS1500

cg13231322

2.21E−06

7.35E−02

2.94

1

32234411

 

IGR

cg24786705

2.25E−06

7.35E−02

2.92

5

34500318

 

IGRa

cg14153321

2.49E−06

7.49E−02

2.82

22

38246051

EIF3L

Body

cg24073755

2.66E−06

7.49E−02

2.76

1

231955433

DISC2

TSS1500

cg02224755

2.82E−06

7.49E−02

2.70

16

1608969

IFT140

Body

cg14788655

3.41E−06

8.33E−02

2.52

11

40224146

LRRC4C

5′UTR

cg25929552

3.53E−06

8.33E−02

2.48

2

67551782

 

IGR

cg01619107

3.94E−06

8.57E−02

2.38

12

52515354

 

IGR

cg10188253

4.22E−06

8.57E−02

2.31

19

43908315

TEX101

5′UTR

  1. Q value indicates FDR corrected p values. B indicates log-odds that the gene is differentially expressed.
  2. Bold letters represent statistically significant results.
  3. aCpGs in two studies: BPD+T vs. BPD-T & CTL and BPD+T vs. BPD-T.
  4. bCpGs in two studies: BPD vs. CTL and BPD+T vs. BPD-T & CTL.