Fig. 3: Regional Manhattan plot of the lead variant rs8052287. | Translational Psychiatry

Fig. 3: Regional Manhattan plot of the lead variant rs8052287.

From: Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality

Fig. 3

This was identified in the gene-based multivariate GEWIS of suicide ideation (Yale-Penn participants of European descent) Functional annotation derived from CADD (Combined Annotation Dependent Depletion) and RegulomeDB scores and 15-core chromatin state information across 13 brain tissues is included below. CADD scores > 20 corresponds to top-1% of pathogenicity across the human genome. RegulomeDB Score = 1 (f to a) corresponds to variants located within a transcription factor binding that shows eQTL activity.

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