Table 3 Top SNPs showing a genome-wide significance or a strong signal for modulating the antidepressant response (P < 9 × 10⁻⁰⁷; Bonferroni correction for the number of SNPs tested as well as the genetic model and stratification by treatment)*.

Chr	SNP	BP	Gene	Location	A1	A2	Treatment response
							NDF	DDF	F	P
Drug-only group
Dominant model
2	rs3783553	113,531,715	IL1A	UTR3	TGAA	-	4	2047	10.69	1.4E−08**
2	rs3783550	113,532,885	IL1A	Intronic	T	G	4	2051	9.97	5.4E−08**
1	rs3817192	204,400,650	PIK3C2B	Intronic	C	A	4	1996	8.60	7.0E−07*
2	rs1609682	113,540,205	IL1A	Intronic	T	G	4	2047	8.30	1.2E−06
2	rs12695032	241,815,473	AGXT	Intronic	A	G	4	2048	7.98	2.2E−06
17	rs183190490	61,557,305	ACE	Intronic	A	G	4	2025	7.87	2.7E−06
10	rs2071426	96,828,323	CYP2C8	Splicing	C	T	4	2031	7.79	3.2E−06
Recessive model
19	rs11671393	3,151,676	GNA15	ncRNA_intron	C	G	4	2048	14.93	5.0E−12**
8	rs4733201	30,670,390	PPP2CB	Upstream	T	G	4	2048	10.84	1.1E−08**
4	rs3749525	66,270,241	EPHA5	Intronic	G	A	4	2048	8.59	7.1E−07*
10	rs11006229	52,350,006	SGMS1	UTR5	T	C	4	2048	8.17	1.6E−06
10	rs1810576	52,220,420	SGMS1	Splicing	C	T	4	2048	8.17	1.6E−06
Plus-rTMS group
Dominant model
1	rs78810070	57,176,393	PRKAA2	UTR3	C	T	4	1495	7.99	2.3E−06
1	rs10797428	2,411,451	PLCH2	Intronic	A	G	4	1531	7.92	2.6E−06
1	rs12727342	2,409,892	PLCH2	Intronic	A	G	4	1520	7.86	2.8E−06
Recessive model
19	rs2303744	48,602,948	PLA2G4C	Exonic	T	C	4	1535	12.85	2.7E−10**
1	rs9628662	155,206,341	GBA	Intronic	T	G	4	1535	11.67	2.5E−09**
1	rs12034326	155,214,473	GBA	UTR5	A	G	4	1535	10.12	4.4E−08**
19	rs1653554	48,608,472	PLA2G4C	Intronic	G	A	4	1535	8.79	5.1E−07*
2	rs7557421	46,207,618	PRKCE	Intronic	A	G	4	1535	8.70	6.0E−07*
17	rs9911574	78,795,868	RPTOR	Intronic	G	A	4	1535	7.94	2.5E−06
19	rs8092	3,123,635	GNA11	UTR3	T	C	4	1535	7.87	2.8E−06

“Drug-only” patients treated with pharmacological agents, and “plus-rTMS” patients treated with pharmacological agents plus rTMS for the first two weeks of the study.
Only SNPs with minor allele frequencies >5% were included for analysis.
The P value indicates the interaction between the time of treatment and the genotype from a general linear random-effect model perspective (coded as a binary variable under a dominant model or a recessive model for convenient interpretation of findings).
**SNPs achieving genome-wide significance; *SNPs with Bonferroni corrections (α = 9.9 × 10⁻⁰⁷).

Search