Fig. 1: Social isolation (SI) did not affect social recognition memory in female mice. | Translational Psychiatry

Fig. 1: Social isolation (SI) did not affect social recognition memory in female mice.

From: Pro-neurogenic effect of fluoxetine in the olfactory bulb is concomitant to improvements in social memory and depressive-like behavior of socially isolated mice

Fig. 1

a Female mice were maintained in groups (control) or isolated (social isolation) during 7 days. Thereafter, animals were submitted to social recognition test for short (STM) and long-term memory (LTM) as well as forced-swimming test (FST). b Both groups presented STM and c LTM, and no difference between groups were detected. d SI increased immobility in female mice (***p < 0.001). e Male mice were maintained in groups (control) or isolated (social isolation) during 7 days. At day 8, animals received a single injection of saline (SAL), fluoxetine (FLX), or desipramine (DES) and 20 min after were exposed to forced-swimming test (FST). f Male mice presented an increase in immobility (depressive-like behavior) after social isolation (##p < 0.01). Fluoxetine, in both doses, decreased immobility in control and SI groups (*p < 0.05; **p < 0.01, and ****p < 0.0001). g Male mice presented an increase in immobility (depressive-like behavior) after social isolation (#p < 0.05). Desipramine, in both doses, decreased immobility in control and SI groups (*p < 0.05; **p < 0.01). h Male mice were maintained in groups (control) or isolated (social isolation) during 7 days. At day 8, animals received a single injection of SAL, FLX, or DES and 20 min after were exposed to the training session of the social recognition test. Twenty-four hours later, the social memory was tested. Results are presented as social recognition index [time exploring the juvenile during TT/time exploring the juvenile during TR + TT]. i SI mice differ from control (#p < 0.05) and acute treatment with antidepressants had no effect. j Male mice were maintained in groups (control) or isolated (social isolation) during 7 days. Every day, animals received a single injection of SAL, FLX, or DES. At day 8, the training session of the social recognition test was performed. Twenty-four hours later, the social memory was tested. Results are presented as social recognition index [time exploring the juvenile during TT/time exploring the juvenile during TR + TT]. k SI mice differ from control (#p < 0.05) and chronic treatment with FLX (*p < 0.05) rescued the social memory deficit of SI mice. Data are presented as mean ± SE.

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