Fig. 2: Antidepressant effect of enriched environment.

a Loss of weight caused by social isolation was prevented by enriched enrichment. p < 0.05 indicates difference within the group and #p < 0.05 indicates difference between groups. b, c Depressive-like behavior in social isolated mice was prevented by the enriched environment (* and ##p < 0.01). d Social isolated mice avoid sucrose solution in the first two hours of exposure (***p < 0.001), while enriched environment prevented such behavior. Data are presented as mean ± SE.