Fig. 4: Variability in sensory-evoked responses is impacted by stress and is related to the frequency of spontaneous sensory motifs.
From: Stress impacts sensory variability through cortical sensory activity motifs
a A representative VSD image of forelimb response to electrical stimulation and traces of evoked responses for control (orange) and stressed (blue) animals. b Stressed animals had increased variability in their evoked response standard deviations (F = 6.05, p < 0.0001). c Variability in forelimb responses to electrical stimulation was linearly related to the frequency of forelimb motifs captured during spontaneous activity sampling prior to stimulation trials (F(1,88) = 21.42, p = 1.3 × 10−5, p-corrected = 3.9 × 10−5). d A representative VSD image of hindlimb response to electrical stimulation and traces of evoked responses. e Stressed and control animals had comparable variability in sensory-evoked responses (F = 0.08, ns); however, f variability in responses was linearly related to the frequency of spontaneous hindlimb motifs during spontaneous activity (F(1,81) = 95.36, p < 0.00001, p-corrected < 0.00001). g A representative VSD image of whisker piezo deflection and traces of evoked responses. h Variability in whisker responses was increased in stressed animals (F = 2.05, p = 0.037), and i variability was linearly related to the frequency of spontaneously occurring whisker motifs (F(1,77) = 85.18, p < 0.00001, p-corrected < 0.00001). For linear regressions, outliers were identified using Tukey’s Fences and excluded. Error bars in graphs represent mean ± standard error.
