Table 2 SNPs associated with clozapine-induced myocarditis with P < 1 × 10−6.

From: Genetic associations with clozapine-induced myocarditis in patients with schizophrenia

rsID

Chr

Base pair

Gene(s)

Location relative to gene

Risk allele/

other allele

Genotype frequency

Risk allele frequency

OR

95% CI

P value

Impute quality

AA AB BB

  

Cases

Controls

Cases

Controls

rs2959223

2

45245165

SIX3, SIX2

Intergenic

A/G

0.38

0.52

0.10

0.08

0.44

0.48

0.64

0.30

5.55

1.44–21.26

3.50E–07

0.99

rs9463787

6

52296583

EFHC1

Intronic

G/A

0.21

0.55

0.24

0.02

0.23

0.76

0.48

0.13

7.67

2.63–22.36

8.08E–07

0.99

rs117188076

8

24401398

ADAM7

Intergenic

T/C

0.01

0.44

0.55

0.00

0.06

0.94

0.23

0.03

13.74

3.68–51.22

2.98E–07

0.89

rs74675399

19

3148869

GNA15

Intronic

A/G

0.04

0.50

0.47

0.00

0.14

0.86

0.28

0.07

6.36

2.28–17.8

1.21E–07

0.88

  1. The most significant variant associated with clozapine-induced myocarditis at each locus is listed.
  2. Chr chromosome, BP base pair positions based on assembly GRCh37.p13 of the human genome, OR odds ratio that reflects the comparison between heterozygotes versus wild-type homozygotes, CI confidence interval.
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