Table 3 Associations of HLA and non-HLA alleles with clozapine-induced myocarditis showing P < 0.05 prior to FDR. Valproate use was included in the analyses as covariate.
From: Genetic associations with clozapine-induced myocarditis in patients with schizophrenia
Allele/supertype | Cases | Controls | OR (95% CI) | Pa | ||
|---|---|---|---|---|---|---|
Carrier | Non-carrier | Carrier | Non-carrier | |||
HLA Class I | ||||||
HLA-B*07:02 | 0.10 | 0.90 | 0.32 | 0.68 | 0.26 (0.07–0.98) | 0.047 |
HLA-C*07:01 | 0.55 | 0.45 | 0.34 | 0.66 | 2.89 (1.11–7.53) | 0.030a |
HLA-C*07:02 | 0.10 | 0.90 | 0.34 | 0.66 | 0.25 (0.07–0.92) | 0.037 |
HLA Class II | ||||||
HLA-DMB*01:01 | 0.76 | 0.24 | 0.52 | 0.48 | 3.22 (1.15–8.97) | 0.026a |
HLA-DQA1*01:02 | 0.17 | 0.83 | 0.45 | 0.55 | 0.23 (0.074–0.71) | 0.011 |
HLA-DQB1*06:02 | 0.10 | 0.90 | 0.35 | 0.65 | 0.17 (0.045–0.69) | 0.012 |
HLA-DRA*01:01 | 0.34 | 0.66 | 0.68 | 0.32 | 0.27 (0.11–0.70) | 0.007 |
HLA-DRB1*15:01 | 0.10 | 0.90 | 0.35 | 0.65 | 0.17 (0.045–0.69) | 0.012 |
Non-HLA | ||||||
MICB*004:01 | 0.21 | 0.79 | 0.48 | 0.52 | 0.27 (0.09–0.77) | 0.015 |
HLA supertype | ||||||
HLA Class II DR1b | 0.17 | 0.83 | 0.39 | 0.61 | 0.28 (0.09–0.89) | 0.031 |
