Table 4 Contribution of clinical and genetic variables to clozapine-induced myocarditis.

From: Genetic associations with clozapine-induced myocarditis in patients with schizophrenia

Variable

Nagelkerke’s r2

P

Clinical only (valproate use)

0.068

0.029

Clinical + HLAa

0.307

0.021

Clinical + HLA + GWASb

0.726

9.838E–09

  1. aIncluded HLA-B*07:02, HLA-C*07:01, HLA-C*07:02, HLA-DMB*01:01, HLA-DQA1*01:02, HLADQB1*06:02, HLA-DRA*01:01, HLA-DRB1*15:01, and MICB*004:01. HLA-DRB1*15:01 was excluded from the model due to redundancy.
  2. bIncluded GWAS top four associations rs2959223, rs9463787, rs117188076, rs74675399. Bold text indicates statistical signifcance P < 0.001.
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