Table 1 Top GWS regions for each biomarker in CSF.

Chr	Index SNP	A1/A2	Freq	ß	p-value	N	Position	KB	Genes	Waves
YKL-40
2	rs150248456	A/G	0.989	−88.276	2.84e-10	2	chr2:125287495..125383005	95.51	*CNTNAP5*	1,3
6	rs11753319^a	C/G	0.951	−39.387	2.89e-08	2	chr6:64902720..65013122	110.40	*EYS*	1,2,3
10	rs182911102^a	T/C	0.985	−64.832	3.15e-08	4	chr10:94991992..95075604	83.61	*FER1L3*	1,2,3
1	rs16856846	A/T	0.020	62.660	4.11e-08	3	chr1:232470911..232485096	14.19		1,2
MCP-1
18	rs10438979^a	A/G	0.960	−230.358	1.64e-09	1	47267946	0	ACAA2	1,2,3
8	rs193114076^a	A/G	0.011	370.998	9.68e-09	3	chr8:34726827..34789467	62.64	LINC01288	1,2,3
1	rs114271760	A/G	0.014	362.410	1.45e-08	5	chr1:184697347..184966318	268.97	FAM129A,EDEM3	1,3
sCD14
8	rs182557857	T/C	0.012	94.392	2.05e-08	4	chr8:96576432..96626315	49.88	*C8orf37-AS1*	1,3
11	rs117456286	A/G	0.013	89.513	4.76e-08	1	62345761	0	*TUT1*	1,3
IL-8
4	rs142700748^a	T/C	0.975	−20.461	2.82e-09	1	234362	0	*ZNF876P*	2,3
3	rs184700722	T/C	0.011	−16.515	4.41e-09	1	162966687	0	*LINC01192*	1,3
2	rs182193570^a	A/G	0.017	26.143	5.79e-09	1	242292698	0	*SEPT2*	2,3
2	rs187443429^a	T/C	0.024	23.725	1.45e-08	1	242392862	0	*FARP2*	2,3
2	rs9646754^a	T/C	0.034	20.001	1.74e-08	1	200300101	0	*SATB2*	1,2,3
2	rs115307848^a	A/G	0.021	22.536	2.79e-08	3	chr2:199894134..200004958	110.82		1,2,3

Genes in bold include the index SNP. Genes not in bold are the gene area that SNPs are closest to. GWS is defined as P < 5e-08. A1/A2, beta (ß), p-value, waves are based on the meta-analysis of GWAS data from each wave. Position is the basepair position or given in UCSC hg19 coordinates.
Chr chromosome, (Index)SNP single nucleotide polymorphism (with the strongest association in the genomic region), A1/A2 reference and alternate allele, Freq weighted average frequency of reference allele, ß random-effects meta-analysis ß estimate, p-value random-effects meta-analysis p-value, N number of SNPs in the reported region, Waves valid waves included for the SNP.
^aResults from meta-analysis including wave 2.

Search