Table 2 Top GWS SNPs for each immune biomarker in blood serum.

From: Genome-wide study of immune biomarkers in cerebrospinal fluid and serum from patients with bipolar disorder and controls

Chr	Index SNP	A1/A2	Freq	ß	p-value	N	Position	KB	Genes	Waves
YKL-40
15	rs188263039	T/G	0.988	−76.738	5.80e-26	1	89809787	0	*FANCI*	1,3
15	rs117809422	A/G	0.015	76.377	7.24e-26	1	89815928	0	*FANCI*	1,3
15	rs188631178	T/C	0.986	−67.032	1.15e-19	1	89845859	0	*FANCI*	1,3
10	rs17602253^a	T/C	0.988	−65.955	1.79e-18	1	18334915	0	SLC39A12	1,2
15	rs62012778^a	A/C	0.966	−37.325	4.41e-15	4	chr15:63818629..63895362	76.73	*USP3,FBXL22*	1,2,3
1	rs116057745^a	A/G	0.982	−31.092	1.47e-14	1	85746632	0		1,2,3
16	rs117868506^a	T/C	0.013	50.578	7.44e-13	2	chr16:1420638..1428236	7.60	*UNKL*	2,3
12	rs117843845^a	T/C	0.020	47.572	9.12e-13	8	chr12:48287373..48314900	27.527	VDR	1,2
3	rs182265848^a	T/G	0.014	58.516	1.05e-12	1	chr3:2579507..2579507	0	CNTN4	2,3
5	rs35017964^a	T/C	0.989	−48.149	1.33e-11	1	chr5:73222206..73222206	0		2,3
2	rs190160997^a	A/C	0.011	45.776	1.58e-10	4	chr2:107295383..107436962	141.579	ST6GAL2	2,3
4	rs116622969^a	T/C	0.983	−36.776	2.80e-10	1	chr4:182066384..182066384	0		1,2,3
16	rs112260868	A/G	0.012	53.408	3.50e-10	1	chr16:21613268..21613268	0	METTL9	1,3
13	rs150949191^a	A/C	0.015	37.114	4.56e-10	2	chr13:109235412..109238352	2.94		2,3
1	rs114751860	T/C	0.013	40.152	5.25e-10	1	chr1:85883897..85883897	0	DDAH1	1,3
18	rs172586^a	A/G	0.020	46.598	8.46e-10	1	chr18:60321603..60321603	0		2,3
18	rs512482^a	T/G	0.978	−24.412	8.81e-10	1	chr18:66119026..66119026	0		2,3
2	rs186493621^a	A/C	0.985	−36.147	9.29e-10	16	chr2:187931545..188399880	468.34	TFPI,CALCRL	2,3
21	rs28707003^a	T/C	0.958	−28.903	1.33e-09	12	chr21:15202015..15222754	20.74		1,2,3
15	rs67659323^a	C/G	0.960	−29,117	2.98e-09	1	chr15:25490757..25490757	0		1,2,3
9	rs117574354	C/G	0.015	25.396	3.08e-09	5	chr9:94685768..94923946	238.178	SPTLC1,ROR2	1,3
2	rs150886752^a	T/C	0.017	40.299	3.36e-09	2	chr2:47882212..47901294	19.08		1,2,3
3	rs34307719^a	T/C	0.987	−45,440	3.38e-09	1	chr3:42943216..42943216	0		1,2
8	rs960667^a	T/G	0.976	−24,890	3.69e-09	5	chr8:126632214..126636054	3.84		1,2
2	rs116200463^a	T/C	0.013	40.224	6.12e-09	3	chr2:107460348..107488170	27.82	ST6GAL2	2,3
1	rs2290199^a	A/G	0.035	20.132	6.21e-09	3	chr1:214825751..214853690	27.94	CENPF	1,2,3
7	rs6969115^a	A/G	0.018	35.247	9.34e-09	18	chr7:30250241..30281728	31.49		1,2
17	rs4791291^a	T/C	0.924	−16,959	1.10e-08	4	chr17:65369397..65396158	26.76	PITPNC1	1,2,3
3	rs192944990^a	T/C	0.012	40.733	1.14e-08	2	chr3:43867670..43888114	20.44		1,2
16	rs138053699^a	A/G	0.019	46.309	1.40e-08	2	chr16:15812581..15821114	8.53	NDE1,MYH11	1,2
2	rs58011745^a	A/G	0.035	25.632	1.68e-08	1	chr2:82922195..82922195	0		1,2,3
4	rs116608013^a	A/C	0.987	−49,182	2.76e-08	1	chr4:2397776..2397776	0	ZFYVE28	1,2
9	rs112153762^a	C/G	0.977	−39,896	3.10e-08	4	chr9:98468727..98480513	11.79		2,3
19	rs118145918^a	T/G	0.024	32.162	3.13e-08	17	chr19:44419463..44487889	68.43	ZNF45,ZNF221	1,2
10	rs113755171^a	T/C	0.011	45.313	3.47e-08	1	chr10:34100343..34100343	0		2,3
6	rs115196122^a	A/G	0.983	−41.511	4.36e-08	3	chr6:159346245..159354145	7.9		1,2
7	rs11979716^a	T/G	0.022	32.630	4.57e-08	8	chr7:30292334..30320400	28.07		1,2
MCP-1
2	chr2_3403609_D^a	D/I8	0.033	254.836	1.70e-08	1	3403609	0	TRAPPC12	1,2,3
sCD14
2	rs190197089^a	T/C	0.015	700.006	2.27e-09	2	chr2:40635776..40659665	0	*SLC8A1*	1,2
5	rs2569191^a	T/C	0.579	−125.703	7.09e-09	110	139779258..140186438	407.18	*ZMAT2,WDR55,TMCO6,SRA1,SLC35A4,PCDHA2,PCDHA3,PCDHA1,NDUFA2,IK,HARS,HARS2,EIF4EBP3,DND1,CD14,APBB3,ANKHD1,ANKHD1-EIF4EBP3*	1,2,3
TIMP-1
14	rs118161330	A/G	0.017	−140.235	2.50e-08	1	33801149	0	*NPAS3*	1,3
TIMP-2
1	chr1_243283251_D^a	D/I6	0.018	54.173	1.24e-08	1	243283251	0		1,2,3
7	rs117145170^a	A/T	0.019	60.350	1.51e-08	1	52273737	0		1,2
18	rs150356358^a	A/G	0.789	−13.907	2.16e-08	36	10640992..10656164	15	LOC101927410	1,2,3
4	rs114147769^a	A/T	0.968	−42.516	2.94e-08	1	162690147	0	*FSTL5*	2,3
log(CRP)
11	rs57213254	T/C	0.011	3.16	5.51e-09	2	chr11:122678513..122679916	1.40	*UBASH3B*	1,3

Bold gene names include the index SNP within the gene. Genes not in bold are those that SNPs are closest to. GWS is defined as P < 5e-08. A1/A2, beta(ß), p-value, waves are based on the meta-analysis of GWAS data from each wave. Position is the basepair position or given in UCSC hg19 coordinates.
Chr chromosome, (Index)SNP single nucleotide polymorphism (with the strongest association in the genomic region), A1/A2 reference and alternate allele, Freq weighted average frequency of reference allele, ß random-effects meta-analysis ß estimate, p-value random-effects meta-analysis p-value, N number of SNPs in the reported region, Waves valid waves included for the SNP.
^aResults from meta-analysis including wave 2.

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Table 2 Top GWS SNPs for each immune biomarker in blood serum.

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