Table 2 PANSS total score and subscores at baseline, week 2, week 4, week 6, and week 8 in 20 Hz rTMS and sham groups.

From: High-frequency neuronavigated rTMS effect on clinical symptoms and cognitive dysfunction: a pilot double-blind, randomized controlled study in Veterans with schizophrenia

 

Baseline (n = 56)

Week 2 (n = 41)

Week 4 (n = 41)

Week 6 (n = 41)

Week 8 (n = 41)

Group F (p value)

Time F (p value)

Group × time F (p value)

PANSS total score

0.57 (0.57)

37.1 (0.00)

1.0 (0.39)

 Sham

79.9 ± 16.9

70.5 ± 17.6

67.8 ± 20.3

67.3 ± 22.4

66.8 ± 22.7

   

 20 Hz

72.3 ± 12.9

67.2 ± 12.3

62.8 ± 13.7

60.6 ± 14.3

59.2 ± 14.4

   

P-subscore

0.54 (0.58)

0.04 (0.83)

0.06 (0.94)

 Sham

11.4 ± 3.6

10.4 ± 2.6

10.3 ± 2.6

10.1 ± 2.8

10.0 ± 2.8

   

 20 Hz

11.3 ± 4.5

11.4 ± 4.8

11.3 ± 4.6

10.9 ± 4.3

10.7 ± 4.3

   

N-subscore

0.1 (0.55)

5.9 (0.00)

0.68 (0.58)

 Sham

31.9 ± 8.4

26.1 ± 8.5

24.8 ± 9.3

24.5 ± 9.8

23.8 ± 10.0

   

 20 Hz

28.7 ± 6.7

25.3 ± 5.9

22.7 ± 6.2

21.5 ± 5.9

20.9 ± 5.9

   

G-subscore

1.3 (0.28)

16.8 (0.00)

1.3 (0.28)

 Sham

36.6 ± 8.7

34.0 ± 8.6

32.7 ± 9.9

32.7 ± 10.8

33.0 ± 10.9

   

 20 Hz

32.3 ± 7.6

30.6 ± 7.1

28.9 ± 7.2

28.3 ± 7.3

27.6 ± 7.5

   

Postive factor

0.72 (0.49)

41.1 (0.00)

0.58 (0.65)

 Sham

5.9 ± 2.5

5.1 ± 1.6

5.0 ± 1.4

5.2 ± 1.7

5.2 ± 1.7

   

 20 Hz

6.6 ± 3.4

6.6 ± 3.2

6.7 ± 3.1

6.6 ± 2.9

6.6 ± 3.0

   

Negative factor

0.72 (0.49)

41.1 (0.00)

0.58 (0.65)

 Sham

26.7 ± 6.9

21.9 ± 7.5

20.6 ± 8.3

20.0 ± 8.5

19.6 ± 8.7

   

 20 Hz

23.8 ± 6.0

20.8 ± 5.7

18.5 ± 5.7

17.5 ± 5.4

17.0 ± 5.5

   

Cognitive factor

1.6 (0.20)

12.9 (0.00)

0.93 (0.44)

 Sham

11.1 ± 3.8

9.8 ± 3.8

9.3 ± 4.2

9.6 ± 4.5

9.3 ± 4.8

   

 20 Hz

8.8 ± 2.5

8.2 ± 2.2

7.7 ± 2.5

7.4 ± 2.6

7.3 ± 2.7

   

Excited factor

0.74 (0.48)

1.6 (0.28)

2.2 (0.074)

 Sham

5.9 ± 2.5

5.5 ± 1.7

5.6 ± 1.7

5.6 ± 1.7

5.7 ± 1.8

   

 20 Hz

5.6 ± 2.2

5.3 ± 1.2

5.2 ± 1.7

4.8 ± 1.3

4.6 ± 1.1

   

Depression factor

0.56 (0.58)

3.3 (0.02)

1.4 (0.20)

 Sham

4.4 ± 1.9

4.3 ± 1.7

4.3 ± 1.7

4.2 ± 1.7

4.2 ± 1.6

   

 20 Hz

4.1 ± 1.9

4.3 ± 2.0

3.9 ± 1.9

4.1 ± 2.0

3.9 ± 2.0

   
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