Table 1 Genome-wide association study sample sizes and SNP-heritability estimates.

From: Genetic overlap between psychotic experiences in the community across age and with psychiatric disorders

 

GWAS N

N cases

QC-positive SNPs

SNP-h2

SE

p

Adolescent psychotic experiences and negative symptom traits

 Paranoia and hallucinations

8665

Continuous

3,363,829

−0.0042

0.0352

0.453

 Cognitive disorganization

6297

Continuous

3,363,829

0.1048

0.0566

0.032

 Anhedonia

6579

Continuous

3,363,829

0.0797

0.0479

0.048

 Parent-rated negative symptoms

10,098

Continuous

3,363,829

−0.0222

0.0316

0.241

Schizotypy during adulthood

 Hypomania

3967

Continuous

5,493,986

0.3732

0.1011

<0.001

 Perceptual aberrations

4057

Continuous

5,493,986

0.3037

0.0916

<0.001

 Physical anhedonia

3988

Continuous

5,493,986

0.3655

0.0965

<0.001

 Social anhedonia

4025

Continuous

5,493,986

0.2950

0.0826

<0.001

Positive psychotic experiences during adulthood

 Auditory hallucinations

117,503

2009

6,443,634

0.0709

0.0255

0.003

 Visual hallucinations

116,787

3768

6,443,706

0.1032

0.0224

<0.001

 Delusions of persecution

117,794

932

6,443,695

0.0910

0.0521

0.040

 Delusions of reference

117,731

822

6,443,693

0.0666

0.0499

0.091

Psychiatric disorders

 Schizophrenia

150,064

36,989

5,274,747

0.1631

0.0044

<0.001

 Bipolar disorder

41,653

20,129

5,083,505

0.2999

0.0102

<0.001

 Major Depression

173,005

59,851

5,488,968

0.0999

0.0042

<0.001

  1. SNP-h2 univariate SNP heritability. SNP-h2 converted to a liability scale for binary traits; effective sample size used for adolescent PENS in LD score regression analyses to account for the presence of siblings (paranoia and hallucinations = 7970.416; cognitive disorganization = 5082.760; anhedonia = 6068.311; parent-rated negative symptoms = 8763.295).
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