Table 2 Comparison of right hemisphere lesions with left hemisphere lesions and with a control sample of stroke lesions.

From: Right-sided brain lesions predominate among patients with lesional mania: evidence from a systematic review and pooled lesion analysis

Area

% lesioned voxelsa (n = 56)

% lesioned voxelsa

Left

Right

p (Sign test)b

Sperber et al. (n = 439)

Barahona-Corrêa et al. (n = 29)

p (Rank-sum test)c

Mean

SD

Mean

SD

Mean

SD

Mean

SD

Grey matter

Frontal

 Precentral gyrus

0.01

0.04

0.01

0.06

n.s.

0.23

0.7

0.01

0.03

0.009

 Superior frontal gyrus

0.09

0.4

0.1

0.48

n.s.

0.05

0.3

0.05

0.16

n.s.

 Superior frontal gyrus, orbital part

0.69

2.08

0.66

2.11

n.s.

0.03

0.25

0.56

2.00

0.005

 Middle frontal gyrus

0.08

0.41

0.14

0.57

n.s.

0.17

0.63

0.09

0.35

n.s.

 Middle frontal gyrus, orbital part

0.49

1.73

0.62

2.09

n.s.

0.07

0.4

0.58

2.20

n.s.

 Inferior frontal gyrus, pars opercularis

0.04

0.24

0.1

0.56

n.s.

1.04

2.24

0.13

0.72

0.0007

 Inferior frontal gyrus, pars triangularis

0.15

0.70

0.15

0.82

n.s.

0.73

1.97

0.20

1.09

0.004

 Inferior frontal gyrus, pars orbitalis

0.5

1.78

0.51

1.78

n.s.

0.17

0.83

0.38

1.36

n.s.

 Rolandic operculum

0.14

0.78

0.14

0.83

n.s.

1.72

3.40

0.24

1.15

0.001

 Supplementary motor area

0

0

0.01

0.07

n.s.

0.04

0.46

0

0

n.s.

 Olfactory cortex

0.43

1.81

0.5

2.08

n.s.

0.03

0.27

0.26

1.07

n.s.

 Medial frontal gyrus

0.11

0.46

0.13

0.58

n.s.

0.04

0.39

0.08

0.39

n.s.

 Medial orbitofrontal cortex

0.89

3.14

0.93

3.18

n.s.

0.04

0.42

0.95

3.13

0.0006

 Rectus gyrus

0.75

2.81

0.8

2.95

n.s.

0

0.07

0.55

2.06

0.005

Temporal and insula

 Hippocampus

0.01

0.06

0.45

1.47

2.0 × 10−5

0.21

0.78

0.57

1.44

9.3 × 10−7

 Parahippocampal gyrus

0.03

0.14

0.68

1.88

0.006

0.09

0.39

0.91

2.20

0.004

 Amygdala

0.05

0.39

0.27

0.86

n.s.

0.07

0.58

0.43

1.08

1.0 × 10−6

 Transverse temporal gyrus (Heschl)

0.12

0.91

0.20

1.06

n.s.

1.73

3.51

0.39

1.46

0.01

 Superior temporal gyrus

0.20

1.03

0.43

1.16

0.01

1.33

2.57

0.66

1.31

n.s.

 Superior temporal pole

0.15

0.73

0.36

0.87

n.s.

0.16

0.61

0.58

1.09

0.0004

 Middle temporal gyrus

0.12

0.55

0.53

1.28

0.008

0.75

1.69

0.82

1.42

n.s.

 Middle temporal pole

0.22

0.98

0.25

0.73

n.s.

0.02

0.26

0.39

0.94

2.1 × 10−18

 Inferior temporal gyrus

0.03

0.1

0.54

1.54

0.01

0.13

0.67

0.76

1.80

5.0 × 10−6

 Insula

0.25

1.06

0.25

0.93

n.s.

1.47

2.59

0.4

1.24

0.02

OCCIPITAL

 Calcarine sulcus

0.01

0.04

0.02

0.11

n.s.

0.23

0.88

0.01

0.05

n.s.

 Cuneus

0

0

0

0

NA

0.09

0.5

0

0

n.s.

 Lingual gyrus

0.002

0.013

0.32

1.08

0.02

0.37

1.4

0.31

1.1

n.s.

 Superior occipital

0.002

0.013

0.003

0.022

n.s.

0.17

0.69

0.01

0.03

n.s.

 Middle occipital gyrus

0.004

0.021

0.02

0.16

n.s.

0.4

1.19

0.04

0.22

0.04

 Inferior occipital

0.005

0.024

0.41

1.64

n.s.

0.26

1.21

0.15

0.59

n.s.

 Fusiform gyrus

0.01

0.08

0.61

1.88

6.0 × 10−5

0.1

0.47

0.76

2.16

9.0 × 10−6

Parietal

 Postcentral gyrus

0.02

0.16

0.02

0.09

n.s.

0.26

0.72

0.01

0.08

0.01

 Superior parietal lobule

0

0

0

0

NA

0.04

0.39

0

0

n.s.

 Inferior parietal lobule

0

0

0

0

NA

0.17

0.89

0

0

n.s.

 Supramarginal gyrus

0.08

0.58

0

0

n.s.

0.64

1.67

0

0

0.002

 Angular gyrus

0.01

0.05

0.002

0.013

n.s.

0.36

1.2

0

0

0.01

 Precuneus

0.002

0.01

0.002

0.013

n.s.

0.05

0.28

0

0

n.s.

 Paracentral lobule

0

0

0.02

0.12

n.s.

0.03

0.42

0

0

n.s.

Cingulum

 Anterior cingulate gyrus

0.23

0.93

0.26

1.19

n.s.

0.06

0.55

0.09

0.35

n.s.

 Midcingulate gyrus

0

0

0.002

0.01

n.s.

0.08

0.56

0

0

n.s.

 Posterior cingulate gyrus

0

0

0

0

NA

0.02

0.31

0

0

n.s.

Subcortical grey matter

 Caudate nucleus

0.04

0.17

0.40

1.05

0.0005

0.71

1.68

0.52

1.13

n.s.

 Putamen

0.02

0.08

0.27

1.21

n.s.

1.65

3.08

0.52

1.66

n.s.

 Globus pallidum

0.06

0.45

0.42

1.53

n.s.

1.15

2.9

0.78

2.07

n.s.

 Thalamus

0.05

0.23

0.55

1.61

0.0005

0.35

1.12

0.75

1.59

0.006

  1. For both analyses, statistical significance was defined using a False Discovery Rate (FDR) of 0.1, according to Benjamini-Hochberg16.
  2. NA not applicable, n.s. non-significant, SD standard deviation.
  3. aDisplayed values are means and standard deviations. Please see Supplementary Table S8 for medians, minimums and maximums.
  4. bp value for Sign tests comparing the left- and right-hemisphere lesion volumes based on quantitative GM and WM analysis. The values being compared reflect the median proportion of voxels in each AAL and JHU atlas area that are included in the lesion.
  5. cp value for Wilcoxon rank-sum tests comparing lesion volumes based on quantitative GM and WM analysis between vascular lesional mania cases and an unselected sample of right-sided stroke described by Sperber and Karnath15. The values being compared reflect the median proportion of voxels in each AAL and JHU atlas area that are included in the lesion.
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