Table 2 Statistical comparisons of left hippocampal subfield volumes (mm3) in FEP and HC.

From: Hippocampal glutamate and hippocampus subfield volumes in antipsychotic-naive first episode psychosis subjects and relationships to duration of untreated psychosis

 

HC (n = 41)

FEP (n = 54)

t(85.7)

P at FDR 0.05

Cohen’s d

Left whole hippocampus

3483.54 (366.9)

3271.4 (346.5)

2.87

<0.01*

0.59

Left hippocampal tail

581.15 (76.80)

553.36 (63.65)

1.89

0.06

0.4

Left subiculum

440.43 (56.17)

413.38 (47.35)

2.53

0.03*

0.53

Left cornu ammonis 1

647.20 (79.45)

596.62 (82.81)

3.04

0.01*

0.62

Left presubiculum

314.66 (39.06)

288.11 (36.14)

3.41

<0.01*

0.71

Left molecular layer

520.10 (961.86)

464.92 (56.83)

2.04

0.06

0.42

Left GC-ML-DG

307.43 (36.76)

289.79 (36.16)

2.35

0.04*

0.48

Left cornu ammonis 3

212.89 (29.70)

201.30 (28.91)

1.91

0.06

0.39

Left cornu ammonis 4

253.50 (29.55)

239.94 (30.04)

2.21

0.04*

0.45

 

FEP subgroup

 

Long DUP (n = 17)

Short DUP (n = 37)

t(26.42)

P at FDR 0.05

Cohen’s d

Left whole hippocampus

3171.42 (388.6)

3317.41 (320.60)

1.45

0.18

−0.42

Left hippocampal tail

538.24 (78.03)

560.30 (55.70)

−1.05

0.46

−0.35

Left subiculum

395.56 (46.68)

421.13 (46.04)

−1.87

0.36

−0.55

Left cornu ammonis 1

574.93 (89.01)

606.58 (79.06)

−1.25

0.46

−0.38

Left presubiculum

275.98 (33.83)

293.68 (36.24)

−1.74

0.36

−0.51

Left molecular layer

480.73 (63.31)

501.42 (53.25)

−1.17

0.46

−0.37

Left GC-ML-DG

282.95 (43.38)

292.94 (32.50)

−0.87

0.46

−0.27

Left cornu ammonis 3

197.35 (31.15)

203.12 (28.08)

−0.65

0.52

−0.21

Left cornu ammonis 4

234.06 (35.81)

242.64 (27.11)

−0.88

0.46

−0.28

  1. All statistical analyses were controlled for multiple comparisons by false detection rate correction method.
  2. HC healthy controls, FEP first episode psychosis’s patients, DUP duration of untreated psychosis (long >12 months > short), GC-ML-DG granular cell of the dentate gyrus.
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