Table 3 Correlations between left hippocampus subfield volumes and DUP, Glx level.

From: Hippocampal glutamate and hippocampus subfield volumes in antipsychotic-naive first episode psychosis subjects and relationships to duration of untreated psychosis

 

HC

FEP all

FEP subgroup

   

Long DUP

Short DUP

 
 

n = 41

n = 54

n = 17

n = 37

t-Test (long vs short)

Hippocampus subfield volumes and DUP

Left whole hippocampus

—

r = −0.37, P < 0.01*

r = −0.05, P = 0.86

r = −0.38, P = 0.02*

P = 0.18; d = −0.42

Left hippocampal tail

—

r = −0.32, P = 0.04*

r = −0.26, P = 0.96

r = −0.37, P = 0.13

P = 0.46; d = −0.35

Left subiculum

—

r = −0.41, P = 0.02*

r = 0.16, P = 0.96

r = −0.42, P = 0.10

P = 0.36; d = −0.55

Left cornu ammonis 1

—

r = −0.31, P = 0.04*

r = −0.04, P = 0.96

r = −0.32, P = 0.16

P = 0.46; d = −0.38

Left presubiculum

—

r = −0.33, P = 0.04*

r = 0.26, P = 0.96

r = −0.26, P = 0.26

P = 0.36; d = −0.50

Left molecular layer

—

r = −0.30, P = 0.04*

r = −0.14, P = 0.96

r = −0.24, P = 0.32

P = 0.46; d = −0.36

Left GC-ML-DG

—

r = −0.20, P = 0.17

r = 0.02, P = 0.96

r = −0.19, P = 0.32

P = 0.46; d = −0.28

Left cornu ammonis 3

—

r = −0.18, P = 0.21

r = −0.12, P = 0.96

r = −0.18, P = 0.32

P = 0.52; d = −0.20

Left cornu ammonis 4

—

r = −0.21, P = 0.17

r = −0.02, P = 0.96

r = −0.18, P = 0.32

P = 0.46; d = −0.28

Hippocampus subfield volumes and Glx level

Left whole hippocampus

r = −0.12, P = 0.47

r = 0.14, P = 0.32

r = 0.47, P = 0.10

r = 0.03, P = 0.88

—

Left hippocampal tail

r = 0.04, P = 0.80

r = 0.22, P = 0.69

r = 0.29, P = 0.43

r = 0.25, P = 0.67

—

Left subiculum

r = −0.20, P = 0.80

r = 0.06, P = 0.69

r = 0.29, P = 0.43

r = 0.06, P = 0.88

—

Left cornu ammonis 1

r = −0.08, P = 0.89

r = 0.06, P = 0.69

r = 0.22, P = 0.47

r = 0.03, P = 0.88

—

Left presubiculum

r = −0.09, P = 0.80

r = 0.10, P = 0.69

r = 0.44, P = 0.26

r = 0.05, P = 0.88

—

Left molecular layer

r = −0.22, P = 0.80

r = 0.13, P = 0.69

r = 0.51, P = 0.26

r = 0.04, P = 0.88

—

Left GC-ML-DG

r = −0.08, P = 0.80

r = 0.08, P = 0.69

r = 0.49, P = 0.26

r = −0.22, P = 0.67

—

Left cornu ammonis 3

r = −0.06, P = 0.80

r = 0.07, P = 0.69

r = 0.26, P = 0.43

r = −0.03, P = 0.88

—

Left cornu ammonis 4

r = −0.05, P = 0.80

r = 0.06, P = 0.69

r = 0.45, P = 0.26

r = −0.20, P = 0.67

—

  1. Pearson partial correlation coefficients were used to assess relationships between the left hippocampus subfields and DUP or glutamate (with controlling variables, for DUP: age, gender, and ICV; for glutamate level: age, gender, tobacco taking (pack-day), and ICV); all statistical analyses were controlled for multiple comparisons by false detection rate correction.
  2. FEP first episode psychosis’s patients, DUP duration of untreated psychosis (long > 12 months > short), BPRS brief psychiatric rating scale, GC-ML-DG granular cell of the dentate gyrus, d Cohen’s d.
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