Fig. 4: Pairwise genic meta-analysis of schizophrenia and other psychiatric disorders. | Translational Psychiatry

Fig. 4: Pairwise genic meta-analysis of schizophrenia and other psychiatric disorders.

From: Pairwise common variant meta-analyses of schizophrenia with other psychiatric disorders reveals shared and distinct gene and gene-set associations

Fig. 4

Manhattan plot for each meta-analysis which displays the −log10-transformed P value for association for genes which were tagged by at least one SNP in the respective GWAS. The red line represents the Bonferroni threshold for multiple-testing correction (P < 2.7 × 10−6). Genes highlighted on each plot were not Bonferroni significant in the individual GWAS but obtained corrected significance in the meta-analysis, with the most significant of these genes labelled for each plot. a Schizophrenia (SZ) and bipolar disorder (BIP) genic meta-analysis, b Schizophrenia and attention-deficit/hyperactivity disorder (ADHD) genic meta-analysis. c Schizophrenia and autism-spectrum disorder (ASD) genic meta-analysis. Manhattan plots for the meta-analyses with MDD, TS, ED and OCD are presented in Supplementary Fig. 1.

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