Table 2 ADHD-associated differentially methylated regions identified using comb-p.

From: Epigenome-wide association study of attention-deficit/hyperactivity disorder in adults

Chr

Coordinates

Gene annotation

CpGs

Covariates in the model

Min P

P

P.adj

1

111743038- 111743411

DENND2D

cg18924738, cg19269039, cg20317872, cg23184711, cg00619207, cg19268695

Sex, age, batch, smoking score and cell-type composition

8.48E−05

1.26E−10

2.52E−07

Sex, age, batch, smoking score, cell-type composition and PRS

5.19E−06

7.25E−12

1.45E−08

111743200- 111743411

cg18924738, cg19269039, cg20317872, cg23184711, cg00619207, cg19268695

Sex, age, batch and cell-type composition

7.73E−05

3.49E−10

1.23E−06

10

134231487- 134231549

PWWP2B (-0.12 kb)

cg09287328, cg03860038, cg23249922

Sex, age, batch, smoking score and cell-type composition

7.61E−03

1.50E−07

1.80E−03

Sex, age, batch, smoking score, cell-type composition and PRS

4.61E−03

8.49E−08

1.02E−03

Sex, age, batch and cell-type composition

9.41E−04

1.52E−08

1.82E−04

11

69241075- 69241093

LOC102724265 / AK094674

cg22203628, cg13647725

Sex, age, batch, smoking score and cell-type composition

7.61E−03

1.18E−07

4.86E−03

Sex, age, batch, smoking score, cell-type composition and PRS

2.28E−03

1.84E−08

7.60E−04

Sex, age, batch and cell-type composition

1.92E−03

6.18E−08

2.55E−03

21

43823797- 43823863

UBASH3A ( + 0.11 kb)

cg20272209, cg27280688, cg10690747, cg13578652

Sex, age, batch, smoking score and cell-type composition

1.53E−03

1.84E−06

0.02

Sex, age, batch, smoking score, cell-type composition and PRS

4.61E−03

7.84E−06

0.09

43823749- 43823863

cg20272209, cg27280688, cg10690747, cg13578652

Sex, age, batch and cell-type composition

2.52E−04

2.03E−09

1.33E−05

  1. For each region, its coordinates (chromosome and start-end bp), CpGs included, minimum P-value in the region (Min P), non-corrected DMR P-value (P) and corrected P-value (P.adj) are shown along with the gene annotation obtained from the Illumina Human EPIC array annotation file and from UCSC when a gene was not annotated in a region. Results including polygenic risk score (PRS) for ADHD or excluding smoking score as covariate are also shown.
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