Table 2 Statistical analysis of the levels of aspartate and serine enantiomers, d-/total-Asp and d-/total-Ser ratios observed in serum of HS and AD patients.

From: Serum d-serine levels are altered in early phases of Alzheimer’s disease: towards a precocious biomarker

Amino acid

CDR 1 vs. CDR 0

CDR 2 vs. CDR 1

CDR 2 vs. CDR 0

Δ%

P value

Δ%

P value

Δ%

P value

d-Asp

1.58

0.6040

−9.84

0.4733

−8.42

0.9072

l-Asp

23.1

0.2431

4.85

0.2287

29.1

0.0787

Ratio d-/total-Asp

−19.6

0.7017

−27.7

0.2389

−41.8

0.0977

d-Ser

15.9

0.0873

12.5

0.2388

30.2

0.0015

l-Ser

0.79

0.7156

0.33

0.8443

1.12

0.9070

Ratio d-/total-Ser

19.4

0.0336

10.1

0.2400

26.5

0.0016

  1. CDR 0 healthy subjects, CDR 1 mild dementia, CDR 2 moderate dementia. Δ%: variation between compared groups expressed as percentage (Δ% = 100 × ([CDR]n−[CDR]n−1)/[CDR]n−1, where “n” is the CDR score, for CDR 1 vs. CDR 0 and CDR 2 vs. CDR 1, and Δ% = 100 × ([CDR]2 − [CDR]0)/[CDR]0 for CDR 2 vs. CDR 0). P values obtained with non-parametric Mann–Whitney test are indicated for each comparison. Statistically significant P values (P < 0.05) are in bold.
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