Table 3 List of differentially expressed genes at the third trimester of pregnancy associated with changes in depressive symptoms (from the third trimester to 2 months postpartum) at 5% FDR.

From: Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape

Symbol

GnRHa_estradiol

Probe

Chr

P value_EPDSv2

FDR_EPDSv2

logFC_diffEPDSv2

P value_diffEPDSv2

FDR_diffEPDSv2

logFC_PPD

P value_PPD

FDR_PPD

logFC_Dep

P value_Dep

FDR_Dep

SLC12A1

x

6557

15

0.738374001

0.999797241

−0.143662302

3.04E-23

3.91E-19

−1.514853079

3.68E-24

1.58E-20

1.52947173

1.01E-10

4.31E-07

OLFM4

 

10562

13

1.18E-05

0.004714007

−0.09056149

1.85E-12

1.09E-08

−0.047752911

0.714523555

0.99980319

0.03402996

0.86046026

0.99997367

RASAL2

 

9462

1

1.59E-05

0.005845119

−0.096580109

2.55E-12

1.09E-08

−0.496078584

0.000301385

0.08060174

0.63127969

0.00207093

0.99997367

ZFP57

x

346171

6

0.688934236

0.999797241

0.113752939

9.57E-12

3.07E-08

0.629257704

0.000143791

0.04988752

−0.6042326

0.0056805

0.99997367

MUC6

x

4588

11

0.032615955

0.835444211

0.107037187

2.20E-11

5.65E-08

0.068004697

0.67455073

0.99980319

−0.2445742

0.26286793

0.99997367

HBZ

x

3050

16

1.81E-13

7.73E-10

0.08198997

3.96E-11

8.47E-08

1.240623973

8.58E-19

2.75E-15

−0.8915749

1.76E-05

0.02832105

PNMA3

 

29944

X

0.588321779

0.999797241

0.084017297

1.38E-09

2.52E-06

−0.048544382

0.737626973

0.99980319

−0.0740358

0.71439951

0.99997367

RAP1GAP

 

5909

1

0.000417001

0.066086904

−0.084706388

1.69E-09

2.71E-06

−0.700111217

1.09E-07

0.0001401

0.95024605

2.17E-06

0.00537669

IFI27

 

3429

NA

0.491717731

0.999797241

0.088816879

2.79E-09

3.98E-06

1.079393826

5.46E-16

1.40E-12

−0.7622081

8.16E-05

0.10472842

NA

 

54094

NA

6.80E-08

7.08E-05

0.107471759

3.55E-09

4.55E-06

−0.077278025

0.650999011

0.99980319

0.11434726

0.6089463

0.99997367

ENC1

 

8507

5

0.005321833

0.336533844

−0.072184102

1.08E-08

1.26E-05

−0.282262065

0.032073728

0.99980319

0.22215453

0.25746315

0.99997367

LOC100132062

 

100132062

NA

2.74E-59

3.52E-55

−0.09642385

1.86E-08

1.99E-05

−2.079430726

1.58E-33

1.01E-29

2.03759936

5.40E-19

6.94E-15

DEFA1B

 

728358

8

2.73E-09

3.90E-06

−0.082334647

2.83E-08

2.80E-05

0.535661022

5.17E-05

0.02287903

−0.505308

0.00958881

0.99997367

SLC35F1

 

222553

6

0.012780901

0.533803126

−0.070659963

1.20E-07

0.000110253

0.899503922

2.61E-10

4.78E-07

−0.7774074

0.00015966

0.14639261

FAM3B

 

54097

21

0.000506343

0.073862832

−0.081062951

4.36E-07

0.000357438

−1.206842502

2.86E-11

6.13E-08

1.29211562

4.09E-08

0.00013115

A2M

 

2

12

0.125486579

0.999797241

0.074797133

4.46E-07

0.000357438

0.066016866

0.674833048

0.99980319

−0.1488668

0.48318013

0.99997367

RNF182

 

221687

6

0.983664265

0.999797241

−0.08587623

5.84E-07

0.000441361

−0.820514565

1.54E-08

2.47E-05

0.9490668

7.75E-06

0.01421399

CLDND2

 

125875

19

0.401412478

0.999797241

0.070517883

1.26E-06

0.000899767

0.016645892

0.912012943

0.99980319

−0.1021826

0.6269187

0.99997367

COL5A3

x

50509

19

0.172251596

0.999797241

0.071123394

1.60E-06

0.001082012

0.059865205

0.690177553

0.99980319

−0.2220476

0.27428873

0.99997367

ANKRD36B

 

57730

2

0.403733504

0.999797241

0.083729733

1.92E-06

0.001230403

−0.148062332

0.425223241

0.99980319

0.19293391

0.40812337

0.99997367

DEFA4

 

1669

8

3.58E-07

0.000230067

−0.065234631

3.52E-06

0.002148751

0.161740923

0.223459958

0.99980319

−0.0154213

0.93716872

0.99997367

C4BPA

x

722

1

2.91E-10

6.22E-07

−0.051502467

3.73E-06

0.002174605

−0.640051256

6.58E-06

0.00384058

0.82369396

0.00010817

0.11571456

MICU1

 

10367

10

0.008452083

0.439583873

0.071183702

4.67E-06

0.002567843

−0.393099561

0.01809445

0.99980319

0.4094252

0.05992712

0.99997367

CPA5

x

93979

NA

0.000105965

0.026159008

−0.069099835

4.80E-06

0.002567843

−0.119843608

0.448016742

0.99980319

0.19377932

0.35625076

0.99997367

NT5C3A

 

51251

7

0.002112895

0.191346638

0.064676607

5.26E-06

0.002701077

0.00076943

0.995962869

0.99980319

0.01731807

0.935702

0.99997367

GPRC5C

x

55890

17

8.18E-09

9.65E-06

−0.074305012

1.07E-05

0.005302851

0.377528437

0.028969482

0.99980319

−0.3655967

0.09786856

0.99997367

LINC00854

 

100874261

17

0.89885143

0.999797241

0.063317275

1.17E-05

0.005562922

0.107322993

0.468550742

0.99980319

−0.1956506

0.34744068

0.99997367

VNN1

 

8876

6

0.046944791

0.982428275

−0.049143107

1.27E-05

0.005837152

−0.032198571

0.799444025

0.99980319

0.04643599

0.80871155

0.99997367

LTF

 

4057

3

0.000136734

0.031980631

−0.058823471

1.34E-05

0.005903106

−0.464815718

0.000247294

0.07054463

0.38819801

0.0434471

0.99997367

FAM153B

 

202134

5

0.011646873

0.515005387

0.076226915

1.38E-05

0.005903106

−0.354084609

0.063289465

0.99980319

0.35484633

0.13436291

0.99997367

BRSK2

 

9024

11

0.184299576

0.999797241

0.076659523

1.52E-05

0.006217663

−0.440448095

0.0242044

0.99980319

0.37176057

0.12460352

0.99997367

FAM53A

 

152877

4

0.798983611

0.999797241

0.075963322

1.55E-05

0.006217663

0.2412146

0.188313624

0.99980319

−0.268703

0.24084011

0.99997367

ADAMTS15

 

170689

11

1.38E-07

0.000111272

0.066022647

1.68E-05

0.006532214

0.174319176

0.282101731

0.99980319

−0.1148235

0.59692752

0.99997367

COL6A3

 

1293

2

0.307133445

0.999797241

0.062579979

1.91E-05

0.007027999

0.146175885

0.347679407

0.99980319

−0.0608776

0.77358719

0.99997367

LOC100507424

 

100507424

NA

0.123121497

0.999797241

0.054632332

1.92E-05

0.007027999

−0.142127217

0.304077778

0.99980319

0.03929275

0.84720725

0.99997367

OBSCN

 

84033

1

0.722086924

0.999797241

0.050750803

2.28E-05

0.008116835

0.071759756

0.571960158

0.99980319

−0.1721324

0.37273278

0.99997367

HS2ST1

 

9653

1

0.013911554

0.553838011

0.064543649

2.43E-05

0.008422227

0.06095681

0.703847531

0.99980319

−0.071729

0.73247663

0.99997367

NPR2

x

4882

9

0.313616353

0.999797241

0.07470813

2.91E-05

0.009837403

0.015369885

0.929490553

0.99980319

−0.1003678

0.66059056

0.99997367

CLEC12A

x

160364

12

0.000137021

0.031980631

−0.046454778

3.37E-05

0.0109922

0.209864679

0.089891059

0.99980319

−0.0452303

0.81056457

0.99997367

TMEM91

 

641649

19

0.404895127

0.999797241

0.058584845

3.43E-05

0.0109922

−0.070196956

0.64309492

0.99980319

−0.0135671

0.94490559

0.99997367

LINC00189

 

193629

21

0.010618077

0.493855975

0.056343712

3.87E-05

0.012116049

−0.298187073

0.037427634

0.99980319

0.29577551

0.1414945

0.99997367

C4B_2

 

100293534

NA

0.007119309

0.388896016

0.055595437

3.96E-05

0.012116049

0.495547097

0.000181471

0.05762403

−0.170722

0.37935001

0.99997367

PLCH2

 

9651

1

0.121882192

0.999797241

0.053982765

5.72E-05

0.017080892

−0.123053219

0.378586968

0.99980319

−0.0175891

0.92956679

0.99997367

KCNMA1

 

3778

10

0.004948314

0.321229175

0.055323213

6.44E-05

0.018566121

0.115752688

0.43053291

0.99980319

−0.2240934

0.28222647

0.99997367

NPIPB5

 

100132247

16

0.363761914

0.999797241

0.053370079

6.51E-05

0.018566121

0.233122434

0.094712932

0.99980319

−0.358436

0.07588194

0.99997367

LOC100132077

 

100132077

NA

0.003168783

0.252656315

0.055771593

8.95E-05

0.024969396

−0.290148219

0.053014626

0.99980319

0.28559265

0.17196614

0.99997367

CLEC12B

 

387837

12

0.000839057

0.105597818

−0.045399984

0.000104155

0.028447571

−0.125781635

0.339340239

0.99980319

0.28429311

0.14471212

0.99997367

DTX2P1-UPK3BP1-PMS2P11

 

441263

NA

0.697163808

0.999797241

0.054641303

0.00010951

0.029287154

0.019767196

0.891894338

0.99980319

−0.0486238

0.80942813

0.99997367

PRKXP1

 

441733

15

0.989146813

0.999797241

0.047857927

0.000122714

0.03195716

0.264657472

0.053607631

0.99980319

−0.3048762

0.12455578

0.99997367

MAML2

 

84441

11

0.054972619

0.999797241

0.047067694

0.000125186

0.03195716

−0.202750932

0.115280757

0.99980319

0.17016595

0.3787149

0.99997367

DDR1

x

780

6

0.528160627

0.999797241

0.056339661

0.000127967

0.03195716

0.10239741

0.500742883

0.99980319

−0.2130413

0.30183844

0.99997367

CDC42BPG

 

55561

11

0.740909675

0.999797241

0.055678667

0.000129452

0.03195716

0.144699948

0.344577413

0.99980319

−0.2834911

0.17133707

0.99997367

KIF19

 

124602

17

0.674283974

0.999797241

0.064295989

0.000149316

0.036165474

−0.31711123

0.086336356

0.99980319

0.36479985

0.11773515

0.99997367

UBAC2

x

337867

13

0.776875995

0.999797241

0.064645112

0.000163489

0.038864885

−0.115184307

0.521453911

0.99980319

0.09990956

0.66283344

0.99997367

FIBCD1

 

84929

9

0.01477133

0.571957401

0.054000943

0.00016668

0.038903107

0.72292732

2.77E-06

0.00197483

−0.5574507

0.007439

0.99997367

KLRC3

x

3823

12

0.956279673

0.999797241

0.0509244

0.000178701

0.040964013

0.108077118

0.445135655

0.99980319

−0.0246341

0.9013113

0.99997367

RASA2

x

5922

3

0.033272719

0.844114418

0.047235684

0.000183238

0.041267076

−0.267466884

0.043001433

0.99980319

0.26920447

0.16864055

0.99997367

ELANE

 

1991

19

1.15E-13

7.39E-10

−0.055711655

0.000193525

0.042832372

0.120832578

0.374804112

0.99980319

0.09448629

0.63103503

0.99997367

PVALB

 

5816

22

0.006261676

0.365368784

−0.057766662

0.000215201

0.045767566

0.141207644

0.392691699

0.99980319

0.01047018

0.9611797

0.99997367

MS4A3

x

932

11

0.000798942

0.10346369

−0.049997885

0.000218028

0.045767566

−0.082803294

0.53179566

0.99980319

0.19154916

0.3263714

0.99997367

SLC26A3

 

1811

7

0.672369503

0.999797241

0.054041842

0.0002224

0.045767566

0.284708866

0.063130844

0.99980319

−0.1980125

0.34245232

0.99997367

ACHE

 

43

NA

0.994744858

0.999797241

−0.060368494

0.000222854

0.045767566

−0.310915524

0.053342115

0.99980319

0.46295071

0.03073028

0.99997367

ISL2

 

64843

15

0.001486002

0.153837193

−0.048382632

0.000224613

0.045767566

−0.273752693

0.049356113

0.99980319

0.25044517

0.21361948

0.99997367

KRT73

 

319101

12

0.820103696

0.999797241

0.051206891

0.000229713

0.046075372

0.14722346

0.313700428

0.99980319

−0.2500906

0.21348809

0.99997367

ARRDC4

 

91947

15

0.377622927

0.999797241

−0.045100521

0.00023539

0.046487629

−0.486360588

0.000256439

0.07156327

0.43111988

0.02688404

0.99997367

MYH7B

 

57644

20

0.703269593

0.999797241

0.049995062

0.000256825

0.049952474

−0.018903827

0.89554412

0.99980319

−0.0695272

0.73062912

0.99997367

  1. EPDS Edinburgh Postnatal Depression Scale symptoms at 2 months postpartum, diffEPDS difference in EPDS symptoms from the third trimester of pregnancy to 2 months postpartum, PPD EPDS symptoms in the PPD group, Dep EPDS symptoms in the depression group, GnRHa_estradiol genes associated with estradiol in the GnRHa study, FDR P values after False Discovery rate multiple testing.
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